MicroRNA expression profiles discriminate childhood T- from B-acute lymphoblastic leukemia
MicroRNA expression profiles discriminate childhood T- from B-acute lymphoblastic leukemia
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DOI：
10.1002/hon.2567
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发表时间：
2019-02-01
影响因子：
3.3
通讯作者：
Lucena-Silva, Norma
中科院分区：
文献类型：
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作者：
Almeida, Renata Santos;Costa e Silva, Matheus;Lucena-Silva, Norma
microRNA（miRNAs）在生物学和细胞学过程中起着关键作用，寻找功能性标记物对于鉴别诊断、预后和开发新的治疗方案具有重要意义。在这种情况下，我们使用HiSeq 2500平台（Illumina），使用大规模平行测序，评估了表现出T细胞或B细胞急性淋巴细胞白血病（T-ALL或B-ALL）的巴西儿童的骨髓miRNA谱。差异表达分析考虑了留一法和FDR
MicroRNAs (miRNAs) play a critical role on biological and cellular processes; the search for functional markers may be of importance for differential diagnosis, prognosis, and development of new therapeutic regimens. In this context, we evaluated the bone marrow miRNA profile of Brazilian children exhibiting T- or B-cell acute lymphoblastic leukemia (T-ALL or B-ALL), using massive parallel sequencing, using the HiSeq 2500 platform (Illumina). The differential expression analysis was conducted considering a leave-one-out approach and FDR