A network of investigator networks in human genome epidemiology
A network of investigator networks in human genome epidemiology
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DOI：
10.1093/aje/kwi201
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发表时间：
2005-08-15
影响因子：
5
通讯作者：
Khoury, MJ
中科院分区：
文献类型：
--
作者：
Ioannidis, JPA;Bernstein, J;Khoury, MJ
确定复杂、多基因疾病的遗传决定因素的任务受到小型研究、出版和报告偏见以及全球缺乏共同标准的阻碍。作者建议建立一个网络网络，其中包括为人类基因组流行病学研究收集数据的研究人员小组。代表数百个小组的23个研究特定疾病或研究专题的调查人员网络已经加入了这一倡议。对于每个领域，作者目前正在创建已经参加各自网络的团队的核心注册。更广泛的国际登记册将包括同样在同一领域工作的所有其他小组。独立调查人员被邀请加入登记册和现有网络，并在需要时联合起来建立更多的网络。网络网络的目的是登记这些网络、团队和调查人员；成为有关众多网络的信息或与之联系的资源；提供方法支持；促进分析做法的合理设计和标准化；对整个领域进行包容性概述；促进对调查结果的快速确认；并避免重复工作。
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors propose the creation of a network of networks that include groups of investigators collecting data for human genome epidemiology research. Twenty-three networks of investigators addressing specific diseases or research topics and representing several hundreds of teams have already joined this initiative. For each field, the authors are currently creating a core registry of teams already participating in the respective network. A wider international registry will include all other teams also working in the same field. Independent investigators are invited to join the registries and existing networks and to join forces in creating additional ones as needed. The network of networks aims to register these networks, teams, and investigators; be a resource for information about or connections to the many networks; off er methodological support; promote sound design and standardization of analytical practices; generate inclusive overviews of fields at large; facilitate rapid confirmation of findings; and avoid duplication of effort.