Biological characteristics of breast cancer at the primary tumour and the involved lymph nodes
Biological characteristics of breast cancer at the primary tumour and the involved lymph nodes
复制标题
DOI：
10.1111/j.1742-1241.2005.00546.x
复制
发表时间：
2005-09-01
影响因子：
2.6
通讯作者：
Meteoglu, I
中科院分区：
文献类型：
--
作者：
Dikicioglu, E;Barutca, S;Meteoglu, I
以往的研究报道，乳腺癌患者腋窝淋巴结（ALN）雌激素受体（ER）表达较原发灶减少。我们评估了更广泛的投票标记物（ER，孕激素受体（PgR），p53，Ki-67和HER-2/ neu），并比较了22例浸润性导管乳腺癌标本的原发投票和相关ALN的范围和染色强度。在累及的ALN，ER和PgR的阳性染色细胞数量和染色强度均降低（分别为p < 0.001和p = 0.003）。而Ki-67阳性细胞数（p < 0.004）和染色强度增加。HER-2/neu和p53在两个部位的染色差异不显著。ALN原发灶和转移灶的免疫组化染色特征与ALN受累数目无相关性（p > 0.05）。本研究提示ALN转移可能提示ER、PgR和Ki-67在浸润性导管乳腺癌中的表达模式更为不利。
Diminished oestrogen receptor (ER) expression in the involved axillary lymph nodes (ALN) in breast cancer compared with the primary turnout has been reported in previous studies. We have assessed a wider spectrum of turnout markers (ER, progesterone receptor (PgR), p53, Ki-67 and HER-2/ neu) and compared extent and staining intensities at the primary turnout and the involved ALN on specimens of 22 cases with invasive ductal breast cancer. At the involved ALN, both the quantity of positive staining cells and the staining intensities for ER and PgR were decreased (p < 0.001 and p = 0.003, respectively). In contrast, the quantity of positive staining cells (p < 0.004) and the staining intensities for Ki-67 were increased. The differences for HER-2/neu and p53 staining at both sites were insignificant. The immunohistochemical staining properties of both the primary turnout and the ALN metastases showed no correlation with the number of involved ALN (p > 0.05). This study suggested that ALN metastasis might indicate a more unfavourable expression pattern of ER, PgR and Ki-67 in invasive ductal breast cancer.