Folate intake and colorectal cancer risk: A meta-analytical approach
Folate intake and colorectal cancer risk: A meta-analytical approach
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DOI：
10.1002/ijc.20648
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发表时间：
2005-02-20
影响因子：
6.4
通讯作者：
Key, TJ
中科院分区：
文献类型：
--
作者：
Sanjoaquin, MA;Allen, N;Key, TJ
足够的叶酸摄入量可以降低结直肠癌的风险。我们对7项队列研究和9项病例对照研究进行了荟萃分析，这些研究探讨了叶酸摄入量与结直肠癌风险之间的关系。在队列研究中，叶酸摄入量与结直肠癌风险之间的关联对于膳食叶酸更强（仅从食物中摄取叶酸;高与低摄入量的相对风险= 0.75; 95% CI = 0.64-0.89）（叶酸来自食物和补充剂;高摄入与低摄入的相对风险= 0.95，95%CI = 0.81-1.11），研究之间没有显著异质性。病例对照研究之间存在显著异质性。这些结果为叶酸对结直肠癌具有较小保护作用的假设提供了一些支持，但不能排除其他饮食因素的混淆。(C)2004 Wiley-Liss，Inc.
Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was stronger for dietary folate (folate from foods alone; relative risk for high vs. low intake = 0.75; 95% CI = 0.64-0.89) than for total folate (folate from foods and supplements; relative risk for high vs. low intake = 0.95, 95% CI = 0.81-1.11) and there was no significant heterogeneity between studies. There was significant heterogeneity between case-control studies. These results offer some support for the hypothesis that folate has a small protective effect against colorectal cancer but confounding by other dietary factors cannot be ruled out. (C) 2004 Wiley-Liss, Inc.