Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference
Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference
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DOI：
10.1016/s0091-3057(98)00258-5
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发表时间：
1999-05-01
影响因子：
3.6
通讯作者：
Bardo, MT
中科院分区：
文献类型：
--
作者：
Klebaur, JE;Bardo, MT
先前的研究表明，大鼠在新环境中的活动水平可以预测安非他明诱导的运动行为和自我管理的强度，但不能预测安非他明条件下的位置偏好。当一只大鼠暴露在一个不可避免的新环境中时，观察到的活动增加可能反映了压力造成的逃避行为。为了评估自由选择测试中的新颖性方法，我们检查了一种新的测试-操场迷宫-预测苯丙胺(1或3 mg/kg)反应的个体差异的能力。使用操场迷宫将大鼠分为高新奇或低新奇，研究发现，新奇寻求的个体差异并不能预测安非他明在单次或重复注射后引起的运动活动的变化。然而，高新颖性寻求者比低新颖性寻求者表现出更大的苯丙胺条件位置偏好。这些结果支持了新奇寻求和药物奖励在神经药理学上相关的假说。(C)1999年爱思唯尔科学公司。
Previous research has shown that a rat's level of activity in a novel environment can predict the strength of amphetamine-induced locomotor behavior and self-administration, but not amphetamine-conditioned place preference. The increase in activity observed when a rat is exposed to an inescapable novel environment may reflect escape behavior due to stress. To assess approach to novelty in a free-choice test, we examined the ability of a new test, the playground maze, to predict individual differences in response to amphetamine (1 or 3 mg/kg). Using the playground maze to categorize rats as either high or low novelty seekers, it was found that individual differences in novelty seeking did not predict amphetamine-induced changes in locomotor activity following either a single or repeated injections. However, high novelty seekers showed greater amphetamine-conditioned place preference than low novelty seekers. These results provide support for the hypothesis that novelty seeking and drug reward are neuropharmacologically related. (C) 1999 Elsevier Science Inc.