NEUROPHYSIOLOGICAL ANALYSIS OF COMMISSURAL PROJECTIONS TO DENTATE GYRUS OF RAT
NEUROPHYSIOLOGICAL ANALYSIS OF COMMISSURAL PROJECTIONS TO DENTATE GYRUS OF RAT
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DOI：
10.1152/jn.1975.38.1.167
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发表时间：
1975-01-01
影响因子：
2.5
通讯作者：
LYNCH, GS
中科院分区：
文献类型：
--
作者：
DEADWYLER, SA;WEST, JR;LYNCH, GS
应用细胞外场电位和单位记录技术研究了大鼠连合向齿状回投射的电生理特性。结果表明：（1）对侧海马CA 3c/CA 4区是诱发齿状回背叶和腹叶连合场电位的最有效部位; 2)短潜伏期负场电位在齿状回的分子层的位置被限制到一个区域50-100 μ m远侧的颗粒细胞层对应的内三分之一的颗粒细胞树突。3)证明负场电位满足同步激活颗粒细胞的总EPSP的细胞外表示的一些标准。4)从颗粒细胞层记录的单位的短潜伏期驱动证实了连合投射到齿状核的兴奋性。5)连合和内嗅皮层刺激程序的比较表明，由不同的会聚解剖系统引起的场电位被定位在齿状分子层的不同区域内。6)连合电位沿着齿状回隔颞轴的分布表明，在对侧CA 3 c/CA 4区与记录电极同位的刺激部位在诱发这些电位方面是最有效的。7)这些研究结果进行了讨论，参照模式的激活齿状颗粒细胞的连合系统的具体比较，更大的，显然更强大的预测从内嗅皮层。
The electrophysiological properties of the commissural projections to the dentate gyrus of the rat were investigated using extracellular field-potential and unit-recording techniques. The following conclusions with respect to those investigations were obtained: 1) The CA3c/CA4 region of the contralateral hippocampus proved to be the most effective site for eliciting the commissural field potentials in the dentate gyrus dorsal and ventral leaves. 2) The location of the short-latency negative field potential in the molecular layer of the dentate gyrus was restricted to a region 50-100 mum distal to the granule cell layers corresponding to the inner one-third of the granule cell dendrites. 3) The negative field potential proved to satisfy a number of criteria for the extracellular representation of the summed EPSPs of synchronously activated granule cells. 4) The excitatory nature of the commissural projections to the dentate was confirmed by the short-latency driving of units recorded from the granule cell layers. 5) A comparison of both commissural and entorhinal cortical stimulation procedures showed the field potentials elicited by the different convergent anatomical systems to be localized within different regions of the dentate molecular layer. 6) The distribution of commissural potentials along the septotemporal axis of the dentate gyrus indicated that stimulation sites homotopic to the recording electrode in the contralateral CA3c/CA4 region were the most effective in eliciting these potentials. 7) These findings were discussed with reference to the mode of activation of the dentate granule cells by the commissural system with specific comparison to the larger and apparently more powerful projections from the entorhinal cortex.