Pleiotropic function of TRPV4 ion channels in the central nervous system.
Pleiotropic function of TRPV4 ion channels in the central nervous system.
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DOI：
10.1113/ep085790
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发表时间：
2016-12-01
影响因子：
2.7
通讯作者：
Liedtke W
中科院分区：
文献类型：
--
作者：
Kanju P;Liedtke W
TRPV 4离子通道是一种具有多效性功能的机械-TRP通道，在许多不同类型的组织和细胞中表达。它们也被发现与疼痛和炎症有关。研究主要集中在TRPV 4在外周感觉神经元中的作用，但其在中枢神经胶质细胞和神经元中的表达和功能也有记载。在这篇综述中，根据资深作者在最近都柏林生理学会议上的演讲，我们简要回顾了TRPV 4在CNS中的表达和功能的证据，以及TRPV 4功能如何被调节以获得神经精神疾病的治疗益处。本文还将讨论作者实验室最近开发的新型TRPV 4抑制化合物
TRPV4 ion channels are osmo-mechano-TRP channels with pleiotropic function and expression in many different types of tissues and cells. They have also been found involved in pain and inflammation. Studies have focused on the role of TRPV4 in peripheral sensory neurons, but its expression and function in central nervous glial cells and neurons has also been documented. In this overview, based on the senior author’s lecture at the recent physiology meeting in Dublin, we concisely review evidence of TRPV4 expression and function in the CNS, and how TRPV4 function can be modulated for therapeutic benefit of neuro-psychiatric disorders. Novel TRPV4-inhibitory compounds developed recently in the authors’ lab will also be discussed