Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress.
Baseline resting heart rate variability predicts post-traumatic stress disorder treatment outcomes in adults with co-occurring substance use disorders and post-traumatic stress.
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DOI：
10.1111/psyp.13377
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发表时间：
2019-04
期刊：
影响因子：
3.7
通讯作者：
Heather E. Soder;M. Wardle;J. Schmitz;S. Lane;C. Green;Anka A. Vujanovic
中科院分区：
文献类型：
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作者：
Heather E. Soder;M. Wardle;J. Schmitz;S. Lane;C. Green;Anka A. Vujanovic
创伤后应激障碍（PTSD）症状在物质使用障碍（SUD）患者中非常普遍，是一种难以治疗的复杂合并症。治疗结局的预后因素可能表征治疗人群的异质性和/或暗示对改善治疗具有显著意义的作用机制。高频心率变异性（HF-HRV）是情绪调节的生物标志物，情绪调节是通过副交感神经系统对心脏的影响产生适当情绪反应的能力。这项初步研究调查了基线静息HF-HRV用于预测PTSD症状和物质使用结果的效用，对37名患有PTSD症状的SUD参与者进行治疗。参与者完成了SUD的标准认知行为治疗（CBT）或将SUD的CBT与PTSD的认知加工治疗相结合的创伤后应激和物质使用的新型综合治疗。分析表明，较高的HF-HRV预测更大的减少PTSD症状后，这两种类型的治疗。这表明HF-HRV作为PTSD治疗结果的预测因子的预后价值;那些自主情绪调节较差的人通常对心理治疗反应不佳。这种假设生成分析确定了可能在治疗预测中具有实用性的推定生物标志物。
Post-traumatic stress disorder (PTSD) symptoms are highly prevalent among individuals with substance use disorders (SUD), presenting a difficult-to-treat, complex comorbidity. Prognostic factors for treatment outcomes may characterize heterogeneity of the treated population and/or implicate mechanisms of action that are salient for improving treatments. High frequency heart rate variability (HF-HRV) is a suggested biomarker for emotion regulation-the ability to generate appropriate emotional responses via the influence of the parasympathetic nervous system on the heart. This initial study investigated the utility of baseline resting HF-HRV for predicting PTSD symptoms and substance use outcomes following treatment of 37 SUD participants with comorbid PTSD symptoms. Participants completed either standard cognitive- behavioral therapy (CBT) for SUD or a novel treatment of integrated post-traumatic stress and substance use that combined CBT for SUD with cognitive processing therapy for PTSD. Analyses demonstrated that higher HF-HRV predicted greater reduction in PTSD symptoms following both types of treatment. This suggests prognostic value of HF-HRV as a predictor of PTSD treatment outcomes; those with poorer autonomic emotional regulation may not respond as well to psychotherapy in general. This hypothesis-generating analysis identifies a putative biomarker that might have utility in treatment prediction.