BIRTH-WEIGHT AND ADULT HEALTH OUTCOMES IN A BIETHNIC POPULATION IN THE USA
BIRTH-WEIGHT AND ADULT HEALTH OUTCOMES IN A BIETHNIC POPULATION IN THE USA
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DOI：
10.1007/s001250050157
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发表时间：
1994-06-01
期刊：
影响因子：
8.2
通讯作者：
STERN, MP
中科院分区：
文献类型：
--
作者：
VALDEZ, R;ATHENS, MA;STERN, MP
最近的数据表明，低出生体重的成年人比其高出生体重的成年人患缺血性心脏病或一系列被称为IRS的疾病的风险更高，这些疾病包括血脂异常、高血压、不良体脂分布和NIDDM。到目前为止，这些观察仅限于来自联合王国的高加索人。我们通过研究美国两个种族人口中出生体重和成人健康结果的关联，将这些观察扩展到更广泛的人群中。我们将圣安东尼奥心脏研究的564名年轻成年墨西哥裔美国人和非西班牙裔白人男性和女性参与者分为出生体重的三分之，并比较了这些三分之的代谢、人体测量学、血流动力学和人口统计学特征。此外，我们研究了出生体重作为与IRS相关疾病聚集的预测因子，IRS被定义为以下任何两种或两种以上疾病：高血压、NIDDM或糖耐量减低、血脂异常。与出生体重在最高三分位数的人相比，血压正常、出生体重在最低三分位数的非糖尿病患者的空腹血清胰岛素水平显著更高，并有更多的躯干脂肪沉积模式，这与性别、种族和当前的社会经济地位无关。此外，出生体重每减少三分位数，表达IRS的几率增加1.72倍(95%可信区间：1.16-2.55)。这些发现与性别、种族和当前的社会经济地位或肥胖水平无关。总而言之，低出生体重可能是成人慢性疾病发展的一个主要独立危险因素，在普通人群中通常与胰岛素抵抗有关。
Recent data indicate that low-birthweight adults are at a higher risk than their high-birthweight peers of developing ischaemic heart disease or a cluster of conditions known as the IRS, which includes dyslipidaemias, hypertension, unfavourable body fat distribution and NIDDM. Thus far these observations have been limited to Caucasians from the United Kingdom. We extended these observations to a broader segment of the general population by studying the association of birthweight and adult health outcomes in a biethnic population of the United States, We divided a group of 564 young adult Mexican-American and non-Hispanic white men and women participants of the San Antonio Heart Study into tertiles of birthweight and compared metabolic, anthropometric, haemodynamic, and demographic characteristics across these tertile categories. Additionally, we studied birthweight as a predictor of the clustering of diseases associated with the IRS, defined as any two or more of the following conditions: hypertension, NIDDM or impaired glucose tolerance, dyslipidaemia. Normotensive, non-diabetic individuals whose birthweight was in the lowest tertile had significantly higher levels of fasting serum insulin and a more truncal fat deposition pattern than individuals whose birthweight was in the highest tertile, independently of sex, ethnicity, and current socioeconomic status. Also, the odds of expressing the IRS increased 1.72 times (95% confidence interval: 1.16-2.55) for each tertile decrease in birthweight. These findings were independent of sex, ethnicity, and current levels of socioeconomic status or obesity. In conclusion, low birthweight could be a major independent risk factor for the development of adult chronic conditions commonly associated with insulin resistance in the general population.