The Pathologic Complete Response Ratio of Liver Metastases Represents a Valuable Prognostic Indicator.
The Pathologic Complete Response Ratio of Liver Metastases Represents a Valuable Prognostic Indicator.
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肝转移的病理完整反应比表示有价值的预后指标。
DOI：
10.3389/pore.2022.1610663
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发表时间：
2022
期刊：
影响因子：
--
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中科院分区：
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--
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背景和目的：本研究的目的是评估肝转移病理完全缓解率（PCRRLM）在预测结直肠癌肝转移（CRLM）预后和复发中的作用。 方法：共纳入 305 例接受术前化疗并行肝切除术的 CRLM 患者。 PCRRLM 定义为表现出病理完全缓解 (PCR) 的肝转移瘤数量除以切除的肝转移瘤总数。 Kaplan-Meier 方法用于计算生存率，并通过对数秩检验检查差异。进行单变量和多变量分析以确定 PCRRLM、无复发生存期 (RFS) 和总生存期 (OS) 的预测因素。 结果：在纳入的 305 例患者中，44 例（14.4%）的 PCRRLM ≥0.50（包括 PCRRLM = 1），261 例（85.6%）的 PCRRLM <0.50（包括 PCRRLM = 0）。年龄较大（≥55 岁）和癌胚抗原 (CEA) 水平较高（≥5 ng/ml）的患者实现 PCRRLM ≥0.50 的可能性较小。在多变量分析中，PCRRLM≥ 0.50（vs. < 0.50，HR [95% CI]：0.67 [0.46–0.99]，p = 0.043）与更好的 RFS 相关。淋巴结状态阳性（对比阴性，HR [95% CI]：1.46 [1.04–2.05]，p = 0.028）和 TBS ≥5（对比 < 5，HR [95% CI]：1.44 [1.02–2.04]，p = 0.038）与较差的 RFS 相关。 结论：PCRRLM 与术前化疗和 CRLM 切除后的长期 RFS 显着相关。因此，它可能是 CRLM 患者复发的一个有价值的指标。
Background and Objectives: The aim of this study was to evaluate the role of the pathologic complete response ratio of liver metastases (PCRRLM) in predicting the prognosis and recurrence of colorectal cancer liver metastases (CRLM). Methods: A total of 305 CRLM patients who underwent preoperative chemotherapy followed by hepatectomy were included. PCRRLM was defined as the number of liver metastases exhibiting pathologic complete response (PCR) divided by the number of total resected liver metastases. The Kaplan–Meier method was used to calculate survival, and differences were examined by the log-rank test. Univariate and multivariate analyses were performed to identify the predictors of PCRRLM, recurrence-free survival (RFS) and overall survival (OS). Results: Among the 305 included patients, 44 (14.4%) achieved a PCRRLM ≥0.50 (including PCRRLM = 1), and 261 (85.6%) achieved a PCRRLM <0.50 (including PCRRLM = 0). Patients of an older age (≥55 years old) and those with higher carcinoembryonic antigen (CEA) levels (≥5 ng/ml) were less likely to achieve a PCRRLM ≥0.50. In the multivariate analysis, PCRRLM≥ 0.50 (vs. < 0.50, HR [95% CI]: 0.67 [0.46–0.99], p = 0.043) was associated with better RFS. Positive lymph node status (vs. negative, HR [95% CI]: 1.46 [1.04–2.05], p = 0.028) and TBS ≥5 (vs. < 5, HR [95% CI]: 1.44 [1.02–2.04], p = 0.038) were associated with worse RFS. Conclusion: PCRRLM was significantly associated with long-term RFS after preoperative chemotherapy and CRLM resection. Thus, it may be a valuable indicator of recurrence in CRLM patients.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
1.9
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Hayashi M;Inoue Y;Komeda K;Shimizu T;Asakuma M;Hirokawa F;Miyamoto Y;Okuda J;Takeshita A;Shibayama Y;Tanigawa N
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Blumgart, LH
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45.3
作者：
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通讯作者：
Vauthey, Jean-Nicolas
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1.4
作者：
Jung SW;Kim DS;Yu YD;Han JH;Suh SO
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Suh SO