Generation of plane chirality via specific host-guest interaction by a macrocyclic heterocyclophane in the crystal phase
Generation of plane chirality via specific host-guest interaction by a macrocyclic heterocyclophane in the crystal phase
复制标题
晶相中的大环杂环烷通过特定的主客体相互作用产生平面手性
DOI：
10.1007/978-94-009-5376-5_6
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
T. Higuchi
中科院分区：
文献类型：
--
作者：
I. Tabushi;K. Yamamura;H. Nonoguchi;K. Hirotsu;T. Higuchi
大环环番非常适合作为完全人工的主体分子，原因如下：a)非常容易制备，b)定义良好的分子几何、大小或形状，c)关于各种物理化学性质的现成信息，例如宏观构象，内旋转等，以及d)显著的热稳定性或化学稳定性。因此，主机结构可以被设计成使得它们可以具有用于特定客人识别的最合适的尺寸、形状和/或功能。到目前为止，只有非常有限数量的大环环番客体对在结晶态被研究过。到目前为止已知的大多数是与晶格(空穴)夹杂或通道夹杂有关的化合物(表I)。
Macrocyclic cyclophanes are very suitable as completely artificial host molecules for the following reasons: a) very easy preparation, b) the well-defined molecular geometry, size, or shape, c) the readily available information concerning various physicochemical properties, e.g., macroring conformation, internal rotation etc., and d) the remarkable thermal or chemical stability. Thus, the host structures can be designed so that they may have the most appropriate size, shape, and/or functionality for the specific guest recognition. Hitherto, only a very limited number of macrocyclic cyclophane-guest pairs have been studied in the crystalline state. And most of them so far known arelattice (cavity) inclusionorchannel inclusioncompounds (Table I).