A Scoping Review of the Role of Metalloproteinases in the Pathogenesis of Autoimmune Pemphigus and Pemphigoid.
A Scoping Review of the Role of Metalloproteinases in the Pathogenesis of Autoimmune Pemphigus and Pemphigoid.
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DOI：
10.3390/biom11101506
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发表时间：
2021-10-13
期刊：
影响因子：
5.5
通讯作者：
Prime SS
中科院分区：
文献类型：
--
作者：
Cirillo N;Prime SS
天疱疮和类天疱疮疾病是可能危及生命的自身免疫性水疱疾病，其特征分别为上皮内和上皮下水疱形成。在这两个疾病组中，由于细胞间粘附（天疱疮）和细胞-细胞外基质（ECM）粘附（类天疱疮）的破坏，皮肤和/或粘膜起泡。鉴于金属蛋白酶可以靶向细胞粘附分子，本研究的目的是调查这些酶在这些大疱性皮肤病的发病机制中的作用。检查天疱疮和类天疱疮中MMP（基质金属蛋白酶）和ADAM（一种去整合素和金属蛋白酶）蛋白酶家族的研究选自国家医学图书馆（MEDLINE/PubMed）和bioRxiv中发表的文章。进行了多个阶段的筛选，提取相关数据并制表，最终定性分析纳入了29篇文章。大多数文献主要研究MMP家族特定组分在大疱性类天疱疮（BP）中的作用，而关注天疱疮的研究较少。最常研究的金属蛋白酶是MMP-9，其次是MMP-2;其他MMP包括MMP-1、MMP-3、MMP-8、MMP-12和MMP-13。还包括与MMP相关的分子，即ADAM 5、8、10、15、17，以及TIMP-1和TIMP-3。结果表明，在寻常型天疱疮（PV）和BP实验模型中，ADAM 10和MMP-9活性分别是水疱形成所必需的。将MMPs与实验性BP的发病机制联系起来的数据相对较强，但金属蛋白酶参与PV的证据更具有试验性。这些分子代表了开发这些起泡疾病的基于机制的治疗的潜在候选者。
Pemphigus and pemphigoid diseases are potentially life-threatening autoimmune blistering disorders that are characterized by intraepithelial and subepithelial blister formation, respectively. In both disease groups, skin and/or mucosal blistering develop as a result of a disruption of intercellular adhesion (pemphigus) and cell-extracellular matrix (ECM) adhesion (pemphigoid). Given that metalloproteinases can target cell adhesion molecules, the purpose of the present study was to investigate the role of these enzymes in the pathogenesis of these bullous dermatoses. Studies examining MMPs (matrix metalloproteinases) and the ADAM (a disintegrin and metalloproteinase) family of proteases in pemphigus and pemphigoid were selected from articles published in the repository of the National Library of Medicine (MEDLINE/PubMed) and bioRxiv. Multiple phases of screening were conducted, and relevant data were extracted and tabulated, with 29 articles included in the final qualitative analysis. The majority of the literature investigated the role of specific components of the MMP family primarily in bullous pemphigoid (BP) whereas studies that focused on pemphigus were rarer. The most commonly studied metalloproteinase was MMP-9 followed by MMP-2; other MMPs included MMP-1, MMP-3, MMP-8, MMP-12 and MMP-13. Molecules related to MMPs were also included, namely, ADAM5, 8, 10, 15, 17, together with TIMP-1 and TIMP-3. The results demonstrated that ADAM10 and MMP-9 activity is necessary for blister formation in experimental models of pemphigus vulgaris (PV) and BP, respectively. The data linking MMPs to the pathogenesis of experimental BP were relatively strong but the evidence for involvement of metalloproteinases in PV was more tentative. These molecules represent potential candidates for the development of mechanism-based treatments of these blistering diseases.
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影响因子：
6.5
作者：
Le Jan, Sebastien;Plee, Julie;Vallerand, David;Dupont, Aurelie;Delanez, Elodie;Durlach, Anne;Jackson, Patricia L.;Blalock, J. Edwin;Bernard, Philippe;Antonicelli, Frank
通讯作者：
Antonicelli, Frank
影响因子：
3
作者：
Massie, Isobel;Dale, Sarah B.;Daniels, Julie T.
通讯作者：
Daniels, Julie T.
影响因子：
5.6
作者：
Cirillo, Nicola;Lanza, Michele;Lanza, Alessandro
通讯作者：
Lanza, Alessandro
影响因子：
3.8
作者：
Cirillo, N.;Femiano, F.;Lanza, A.
通讯作者：
Lanza, A.
影响因子：
10.3
作者：
Ivars, M.;Espana, A.;Lopez-Zabalza, M. J.
通讯作者：
Lopez-Zabalza, M. J.