cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer
cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer
复制标题
用于体内光热/光声成像和癌症化疗/光热治疗的顺铂前药附着的 CuFeS2 纳米板
DOI：
10.1039/c7nr04166g
复制
发表时间：
2017-11-21
期刊：
影响因子：
6.7
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Ding, Binbin;Yu, Chang;Lin, Jun
光热疗法(PTT)在癌症治疗中引起了广泛的关注。本论文采用模板介导法，成功地合成了形状规整的铜铁硫化物(黄铜矿，CuFeS_2)纳米片。壳聚糖(CS)是一种线性阳离子多糖，用于改善其生理稳定性和生物相容性。具有强近红外(NIR)吸收的CuFeS2纳米粒子在光热和光声(PA)成像中形成了对比。体内外肿瘤消融研究进一步表明，CS功能化的CuFeS2(CuFeS2-CS)纳米粒子能够将808 nm的近红外光转换为热，用于PTT的光热转换效率高达30.5%，明显高于CuS纳米粒子的光热转换效率(仅21.4%)。此外，CuFeS_2-CS纳米粒还可以负载顺铂前体药物(CuFeS_2-CS-PT)，无论是化疗还是PTT，CuFeS_2-CS-PT都表现出更好的协同治疗效果。
Photothermal therapy (PTT) has attracted considerable attention in cancer treatment. Herein, the facile synthesis of copper iron sulfide (chalcopyrite, CuFeS2) nanoplates (NPs) with well-defined shape was achieved by a template-mediated method. Chitosan (CS), a linear cationic polysaccharide, was used to improve the physiological stability and biocompatibility. CuFeS2 NPs with strong near-infrared (NIR) absorbance enabled contrasts in photothermal and photoacoustic (PA) imaging. In vitro and in vivo tumor ablation studies further demonstrated that CS-functionalized CuFeS2 (CuFeS2-CS) NPs could convert 808 nm NIR light into heat for PTT with a photothermal conversion efficiency up to 30.5%, which was clearly higher than that of CuS NPs (only 21.4%). Furthermore, CuFeS2-CS NPs could also load cis-platinum pro-drug (CuFeS2-CS-Pt), and CuFeS2-CS-Pt showed a better synergistic therapeutic effect with respect to either chemotherapy or PTT.