Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.
Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.
复制标题
肿瘤表型营养调节的证据：酪氨酸和苯丙氨酸限制的影响。
DOI：
10.1007/978-1-4899-0939-8_13
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发表时间：
1994
影响因子：
--
通讯作者：
Starkey,JR
中科院分区：
文献类型：
--
作者：
Elstad,CA;Meadows,GG;Aslakson,CJ;Starkey,JR
营养和癌症之间的联系是有据可查的，但也很复杂，常常令人困惑。营养因子与癌症进展、癌症预防和化疗有关。碳水化合物、1,2脂肪、3 - 7维生素、8 - 10和其他微量元素不仅改变肿瘤表型（包括生长、形态学、膜特征、15、16和转移潜能17、18），而且还改变宿主对肿瘤的反应。19 - 21利用肿瘤细胞与正常细胞在营养需求上的差异，对饮食中的氨基酸进行调控可以产生抗肿瘤活性14,15,22。例如，一些肿瘤系统的蛋氨酸依赖性已被用来优先抑制肿瘤生长。22 - 27此外，l-天冬酰胺酶作为抗白血病药物已取得临床成功28 - 30
The link between nutrition and cancer is well documented, but also complex and oftentimes confusing. Nutritional factors are implicated in cancer progression, cancer prevention, and chemotherapy. Carbohydrates,1,2fats,3–7vitamins,8–10and other trace elements11–13alter not only tumor phenotype—including growth,14morphology,15membrane characteristics,15,16and metastatic potential17,18—but also host responses to tumor.19–21Dietary manipulation of amino acids, which exploits differences in nutritional requirements of tumor cells compared with normal cells,14,15,22can yield antitumor activity. For example, methionine dependence of several tumor systems has been utilized to preferentially inhibit tumor growth.22–27Additionally,l-asparaginase has achieved clinical success as an antileukemic drug.28–30