Incidence of gastroesophageal reflux during transpyloric feeds.
Incidence of gastroesophageal reflux during transpyloric feeds.
复制标题
经幽门进食期间胃食管反流的发生率。
DOI：
10.1097/mpg.0b013e31820596f8
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发表时间：
2011
影响因子：
2.9
通讯作者：
Warlaumont,Mary
中科院分区：
文献类型：
--
作者：
Rosen,Rachel;Hart,Kristen;Warlaumont,Mary
目的：经幽门喂养已被提议作为控制胃食管反流的一种替代方法，但尚未有儿科研究确定经幽门喂养如何影响反流负担。本研究的目的是确定接受幽门喂养的患者的反流负担。患者和方法：我们回顾了在多通道腔内阻抗记录期间持续症状并经门静脉喂养的患者的多通道腔内阻抗追踪。我们比较了进料期和非进料期的回流曲线。我们还比较了波士顿儿童医院（Children’s Hospital Boston）在开始进行幽门喂养前后一年因反流而住院的人数。结果：饲喂期和非饲喂期平均每小时反流次数分别为1.4±1.3次和0.8±1.1次（P= 0.06）。饲喂期大鼠在食道停留的时间百分比（1.0%±1.4%）与非饲喂期（0.6%±1.1%，P= 0.5）比较，差异无统计学意义。在开始进食前（1.2±1.4）和开始进食后（1.4±1.2，P= 0.7）的一年内，与反流相关的平均住院次数无显著差异。结论：与非喂养期相比，幽门喂养期的反流发生率更高，这可能解释了为什么一些患者在开始幽门喂养后仍有反流相关的住院治疗。
Objectives:Transpyloric feeding has been proposed as an alternative method for controlling gastroesophageal reflux, but there have been no pediatric studies to determine how transpyloric feeding affects reflux burden. The aim of the present study was to determine the reflux burden in patients receiving transpyloric feeds.Patients and Methods:We reviewed the multichannel intraluminal impedance tracings of patients who had persistent symptoms and were fed transpylorically during the multichannel intraluminal impedance recording. We compared the reflux profiles during feed and nonfeed periods. We also compared the number of reflux-related hospitalizations at Children's Hospital Boston in the year before and the year after the initiation of transpyloric feeds.Results:The mean number of reflux events per hour was 1.4±1.3 and 0.8±1.1 during feed and nonfeed periods, respectively (P= 0.06). There was no significant difference in the percentage of time that boluses were present in the esophagus during feed periods (1.0%±1.4%) compared with the nonfeed periods (0.6%±1.1%, P= 0.5). There was no significant difference in the mean number of reflux-related hospitalizations in the year before (1.2±1.4) or after (1.4±1.2, P= 0.7) the initiation of transpyloric feeds.Conclusions:There is more reflux during transpyloric feeding periods than nonfeeding periods, which may explain why some patients continue to have reflux-related hospitalizations even after the initiation of transpyloric feeds.