Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice
Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice
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DOI：
10.1016/j.nlm.2007.07.015
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发表时间：
2007-11-01
影响因子：
2.7
通讯作者：
Frick, Karyn M.
中科院分区：
文献类型：
--
作者：
Gresack, Jodi E.;Kerr, Kristin M.;Frick, Karyn M.
本研究旨在研究终生暴露在标准或丰富的住房中是否会影响雌激素在整个生命周期中改善空间和物体记忆的能力。三周大的雌性小鼠在 5、17 或 22 个月大时一直被饲养在标准或丰富的住房中，直到进行卵巢切除和行为测试。在莫里斯水迷宫中测试空间记忆，并使用物体识别任务测试物体记忆。每天训练后，立即向小鼠腹膜内注射媒介物或0.2 mg/kg 17 β-雌二醇。在年轻女性中，单独使用雌二醇可以增强物体识别能力，但这种效果会因雌二醇丰富而减弱。相比之下，单独使用雌二醇会损害空间水迷宫的表现，但雌二醇和浓缩物的结合会改善空间水迷宫的表现。到了中年，雌二醇或单独使用浓缩物以及两种治疗相结合可以增强物体识别能力。这两种治疗方法也改善了中年人在水迷宫中的空间记忆，但雌二醇的有益作用仅限于标准饲养的雌性。最后，虽然老年女性的丰富性显着提高了这两项任务的表现，但雌二醇在该年龄的这两项任务中都没有影响。总的来说，数据表明，终生丰富可以显着改变雌二醇对小鼠整个生命周期记忆的影响程度。重要的是，这些治疗之间的相互作用很大程度上取决于年龄和测试的记忆类型。 (C) 2007 Elsevier Inc. 保留所有权利。
The present study was designed to examine whether life-long exposure to standard or enriched housing affects the ability of estrogen to improve spatial and object memory throughout the lifespan. Three-week-old female mice were maintained in standard or enriched housing up to and through ovariectomy and behavioral testing at 5, 17, or 22 months of age. Spatial memory was tested in the Morris water maze and object memory was tested using an object recognition task. Immediately after training each day, mice were injected intra-peritoneally with vehicle or 0.2 mg/kg 17 beta-estradiol. Among young females, object recognition was enhanced by estradiol alone, an effect that was reduced by enrichment. In contrast, spatial water maze performance was impaired by estradiol alone, but improved by the combination of both estradiol and enrichment. At middle-age, object recognition was enhanced by estradiol or enrichment alone, and the combination of both treatments. Spatial memory in the water maze was also improved by both treatments at middle-age, but the beneficial effects of estradiol were limited to standard-housed females. Finally, whereas enrichment in aged females significantly enhanced performance in both tasks, estradiol had no effect at this age in either task. In total, the data indicate that life-long enrichment can significantly alter the extent to which estradiol affects memory in mice throughout the lifespan. Importantly, the interaction between these treatments is highly dependent on age and type of memory tested. (C) 2007 Elsevier Inc. All rights reserved.