No exercise-induced increase in serum BDNF after cycling near a major traffic road
No exercise-induced increase in serum BDNF after cycling near a major traffic road
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DOI：
10.1016/j.neulet.2011.06.019
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发表时间：
2011-08-15
影响因子：
2.5
通讯作者：
Meeusen, R.
中科院分区：
文献类型：
--
作者：
Bos, I.;Jacobs, L.;Meeusen, R.
骑自行车上下班有明显的健康促进作用。此外，众所周知，定期锻炼可以改善大脑可塑性，从而增强认知和记忆能力。动物研究清楚地表明，运动可以上调脑源性神经营养因子（BDNF - 一种神经营养因子），从而增强大脑的可塑性。对人类的研究发现，剧烈运动后血清 BDNF 浓度会增加。最近，越来越多的证据表明，与汽车司机相比，骑自行车通勤的人接触空气污染（例如颗粒物 (PM)）的程度更高。此外，接触 PM 与神经系统的负面影响有关，例如神经炎症和认知能力下降。我们进行了一项交叉实验，以检查运动对血清 BDNF 的急性影响，以及暴露于交通相关空气污染的潜在影响。 38 名身体健康、无哮喘的志愿者（平均年龄：43 岁，26% 为女性）进行了两项自行车试验，一项在主要交通道路（安特卫普环路，R1 每天最多 260,000 辆车）附近进行，另一项在空气过滤室中进行。空气过滤室是通过减少细颗粒和超细颗粒（UFP）而创建的。测量了 PM10、PM2.5 和 UFP。两次自行车试验中，每位志愿者的自行车持续时间（类似于 20 分钟）和强度均保持相同。在每次循环试验之前和之后 30 分钟测量血清 BDNF 浓度。在大环路附近骑行时，PM10和PM2.5的平均浓度分别为64.9μg/m(3)和24.6μg/m(3)，而空气过滤室内的PM10和PM2.5平均浓度分别为7.7μg/m(3)和2.0μg/m(3)。道路沿线 UFP 的平均浓度为 28,180 个颗粒/cm(3)，而空气过滤室中的平均浓度为 496 个颗粒/cm(3)。正如预期的那样，在空气过滤室骑自行车后，运动显着增加了血清 BDNF 浓度（+14.4%；p=0.02）。相比之下，在主要交通路线附近骑自行车后，血清 BDNF 浓度并未增加（+0.5%；p = 0.42）。尽管积极的通勤被认为对健康有益，但在高浓度 PM 的环境中锻炼可能会对这种健康促进作用产生负面影响。必须进一步阐明长期运动和长期暴露是否也存在这种效应。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Commuting by bike has a clear health enhancing effect. Moreover, regular exercise is known to improve brain plasticity, which results in enhanced cognition and memory performance. Animal research has clearly shown that exercise upregulates brain-derived neurotrophic factor (BDNF - a neurotrophine) enhancing brain plasticity. Studies in humans found an increase in serum BDNF concentration in response to an acute exercise bout. Recently, more evidence is emerging suggesting that exposure to air pollution (such as particulate matter (PM)) is higher in commuter cyclists compared to car drivers. Furthermore, exposure to PM is linked to negative neurological effects, such as neuroinflammation and cognitive decline. We carried-out a cross-over experiment to examine the acute effect of exercise on serum BDNF, and the potential effect-modification by exposure to traffic-related air pollution. Thirty eight physically fit, non-asthmatic volunteers (mean age: 43, 26% women) performed two cycling trials, one near a major traffic road (Antwerp Ring, R1 up to 260,000 vehicles per day) and one in an air-filtered room. The air-filtered room was created by reducing fine particles as well as ultrafine particles (UFP). PM10, PM2.5 and UFP were measured. The duration (similar to 20 min) and intensity of cycling were kept the same for each volunteer for both cycling trials. Serum BDNF concentrations were measured before and 30 min after each cycling trial. Average concentrations of PM10 and PM2.5 were 64.9 mu g/m(3) and 24.6 mu g/m(3) in cycling near a major ring way, in contrast to 7.7 mu g/m(3) and 2.0 mu g/m(3) in the air-filtered room. Average concentrations of UFP were 28,180 particles/cm(3) along the road in contrast to 496 particles/cm(3) in the air-filtered room. As expected, exercise significantly increased serum BDNF concentration after cycling in the air-filtered room (+14.4%; p=0.02). In contrast, serum BDNF concentrations did not increase after cycling near the major traffic route (+0.5%; p = 0.42). Although active commuting is considered to be beneficial for health, this health enhancing effect could be negatively influenced by exercising in an environment with high concentrations of PM. Whether this effect is also present with chronic exercise and chronic exposure must be further elucidated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.