Mortality study of ethylene oxide workers in chemical manufacturing: a 10 year update.
Mortality study of ethylene oxide workers in chemical manufacturing: a 10 year update.
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化学制造中环氧乙烷工人的死亡率研究：十年更新。
DOI：
10.1136/oem.50.8.704
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
J. Vitale
中科院分区：
文献类型：
--
作者：
M. Teta;L. Benson;J. Vitale
从 1940 年到 1988 年，对分配到通过氯醇或直接氧化工艺生产环氧乙烷的装置以及两个化工厂使用环氧乙烷的其他部门的人员进行了死亡率追踪（n = 1896）。根据截至 1978 年底对这些工人进行的一项研究结果，该研究确定了混杂暴露，分配到环氧乙烷暴露潜力较低的单位的工人被排除在外 (n = 278)。平均暴露时间超过 5 年，平均随访时间为 27 年，所有受试者距首次暴露至少 10 年。数据并不支持环氧乙烷与所有癌症类型、白血病、非霍奇金淋巴瘤或脑癌、胰腺癌或胃癌之间的关联。也没有持续时间反应趋势。总癌症的标准化死亡率 (SMR) 为 86（95% 置信区间 71-104），并且对于最早受聘且工作时间较长的人员来说，死亡率并没有增加。本次 10 年更新的结果以及最近对环氧乙烷工人进行的其他研究的结果并未证实动物研究的结果，并且与环氧乙烷工人中报告的最早结果不一致。
Men assigned to units producing ethylene oxide by the chlorohydrin or direct oxidation processes and to other departments using ethylene oxide in two chemical plants were followed up for mortality from 1940 to 1988 (n = 1896). Based on findings from a previous study of these workers to the end of 1978, which identified confounding exposures, workers assigned to one unit with low ethylene oxide exposure potential were excluded (n = 278). Average duration of exposure was over five years and average follow up was 27 years, with all subjects at least 10 years from first exposure. The data did not support associations of ethylene oxide with all cancer types combined, leukaemia, non-Hodgkin's lymphoma, or brain, pancreatic, or stomach cancers. There were also no duration-response trends. The standardised mortality ratio (SMR) for total cancer was 86 (95% confidence interval 71-104) and did not increase for those hired the earliest and with long duration assignments. The results of this 10 year update and those of other recent studies of ethylene oxide workers do not confirm findings from animal studies and are not consistent with the earliest results reported among ethylene oxide workers.