The current and future therapies of bone regeneration to repair bone defects.
The current and future therapies of bone regeneration to repair bone defects.
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DOI：
10.1155/2012/148261
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发表时间：
2012
影响因子：
2.1
通讯作者：
Fukushima H
中科院分区：
文献类型：
--
作者：
Jimi E;Hirata S;Osawa K;Terashita M;Kitamura C;Fukushima H
骨缺损通常由肿瘤切除、先天畸形、创伤、骨折、手术或牙科牙周炎引起。尽管牙科植入物是从牙齿缺陷中恢复口腔功能的有效治疗方法，但许多患者没有足够的骨体积来构建植入物。大面积骨缺损重建的金标准是使用自体骨移植。虽然自体骨移植是最有效的临床方法，但对被提取骨部分的手术应力和可提取骨的量限制了该方法。近年来，间充质干细胞疗法有望成为治疗骨缺损的有效方法。在本文中，我们讨论了目前的治疗骨再生和干细胞为基础的再生医学领域的前景，解决干细胞和生长因子的来源，用于诱导骨再生有效和可重复。
Bone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an implant. The gold standard for the reconstruction of large bone defects is the use of autogenous bone grafts. While autogenous bone graft is the most effective clinical method, surgical stress to the part of the bone being extracted and the quantity of extractable bone limit this method. Recently mesenchymal stem cell-based therapies have the potential to provide an effective treatment of osseous defects. In this paper, we discuss both the current therapy for bone regeneration and the perspectives in the field of stem cell-based regenerative medicine, addressing the sources of stem cells and growth factors used to induce bone regeneration effectively and reproducibly.