Receptors for purines and pyrimidines.
Receptors for purines and pyrimidines.
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DOI：
10.1007/978-3-642-28863-0_5
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发表时间：
1998-09
影响因子：
21.1
通讯作者：
V. Ralevic;G. Burnstock
中科院分区：
文献类型：
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作者：
V. Ralevic;G. Burnstock
嘌呤和嘧啶的细胞效应通过嘌呤受体的扩展超家族介导，其包括代谢型P1（腺苷）受体和P2核苷酸受体，进一步细分为离子型P2X受体（ATP门控阳离子通道）和代谢型P2Y受体（G蛋白偶联）。本章提供了嘌呤受体的分子生物学、生物物理学、药理学、生理学和分布的深入概述。
The cellular effects of purines and pyrimidines are mediated through an extended superfamily of purinoceptors, which include metabotropic P1 (adenosine) receptors, and P2 nucleotide receptors, further subdivided into ionotropic P2X receptors (ATP-gated cation channels) and metabotropic P2Y receptors (G protein-coupled). This chapter provides in‐depth overview of molecular biology, biophysics, pharmacology, physiology, and distribution of purinoceptors.