TRPV4 and the regulation of vascular tone.
TRPV4 and the regulation of vascular tone.
复制标题
TRPV4 和血管张力的调节。
DOI：
10.1097/fjc.0b013e318279ba42
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发表时间：
2013-02
影响因子：
3
通讯作者：
Rath G
中科院分区：
文献类型：
--
作者：
Filosa JA;Yao X;Rath G
最近的研究已经介绍了瞬时受体电位香草酸亚型4（TRPV 4）通道在调节血管张力中的重要性。TRPV 4通道在内皮细胞和血管平滑肌细胞中表达，并且可以被多种刺激激活，包括机械刺激（例如剪切应力、细胞肿胀和热）和化学刺激（例如环氧二十碳三烯酸（Escherichia coli，Escherichia coli，Escherichia coli）、内大麻素、4α-佛波酯）。在大脑中，TRPV 4通道主要定位于缠绕血管的星形胶质细胞终足突起。因此，TRPV 4通道被策略性地定位以感知血液动力学变化并有助于调节血管张力。TRPV 4通道激活导致平滑肌细胞超极化和血管舒张。在这里，我们回顾了TRPV 4介导的血管舒张，TRPV 4通道与其他蛋白质，包括瞬时受体电位通道1（TRPC 1），小电导（KCa2.3）和大电导（KCa1.1）的钙激活，钾选择性通道和这些相互作用发生的小窝蛋白丰富的域的重要性的细胞机制的最新发现。
Recent studies have introduced the importance of Transient Receptor Potential Vanilloid Subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (e.g. shear stress, cell swelling, and heat) and chemical (e.g. epoxyeicosatrienoic acids (EETs), endocanabinoids, 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation, TRPV4 channel interaction with other proteins including Transient Receptor Potential Channel 1 (TRPC1), small conductance (KCa2.3) and large conductance (KCa1.1) calcium-activated, potassium-selective channels and the importance of caveolin-rich domains for these interactions to take place.