Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women
Consumption of Fructose and High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, and Apolipoprotein-B in Young Men and Women
复制标题
DOI：
10.1210/jc.2011-1251
复制
发表时间：
2011-10-01
影响因子：
5.8
通讯作者：
Havel, Peter J.
中科院分区：
文献类型：
--
作者：
Stanhope, Kimber L.;Bremer, Andrew A.;Havel, Peter J.
内容：美国心脏协会营养委员会建议女性和男性每天摄入的添加糖分别不超过100和150千卡，而2010年美国人膳食指南建议最大添加糖摄入量为总能量的25%或更少。目的：为了解决这一差异，我们比较了摄入葡萄糖，果糖，或高果糖玉米糖浆（HFCS）在能量需求（E）的25%时对心血管疾病风险因素的影响。（年龄18-40岁;体重指数18-35 kg/m2）在临床研究中心进行3.5天的基线测试，同时消耗含有55% E复合碳水化合物的能量平衡饮食。在12个门诊日，他们食用通常的自由饮食沿着，每天三份葡萄糖、果糖或HFCs加糖饮料（n = 16/组），提供25%的E需求。受试者在3.5 d的住院干预试验中摄入能量平衡的饮食，饮食中含有25%的E含糖饮料/30%的E复合碳水化合物。主要结果测量：24小时甘油三酯曲线下面积、空腹血浆低密度脂蛋白（LDL）和载脂蛋白B（apoB）浓度。在果糖摄入期间，24小时甘油三酯曲线下面积较基线增加（+4.7 +/-1.2 mmol/L × 24 h，P = 0.0032）和HFCS（+1.8 +/-1.4 mmol/L × 24 h，P = 0.035），但不含葡萄糖（-1.9 +/-0.9 mmol/L × 24 h，P = 0.14）。空腹LDL和apoB浓度在果糖摄入期间增加（LDL：+0.29 +/- 0.082 mmol/L，P = 0.0023; apoB：+0.093 +/- 0.022 g/L，P = 0.0005）和HFCS（LDL：+0.42 +/- 0.11 mmol/L，P < 0.0001; apoB：+0.12 +/- 0.031 g/L，P < 0.0001）但不含葡萄糖（LDL：+0.012 +/- 0.071 mmol/L，P = 0.86; apoB：+0.0097 +/- 0.019 g/L，P = 0.90）。在年轻人中，以25%E摄入HFCs加糖饮料2周增加了心血管疾病的危险因素，其中果糖增加的危险因素多于葡萄糖。（临床内分泌代谢杂志96：E1596-E1605，2011）
Context: The American Heart Association Nutrition Committee recommends women and men consume no more than 100 and 150 kcal of added sugar per day, respectively, whereas the Dietary Guidelines for Americans, 2010, suggests a maximal added sugar intake of 25% or less of total energy.Objective: To address this discrepancy, we compared the effects of consuming glucose, fructose, or high-fructose corn syrup (HFCS) at 25% of energy requirements (E) on risk factors for cardiovascular disease.Participants, Design and Setting, and Intervention: Forty-eight adults (aged 18-40 yr; body mass index 18-35 kg/m(2)) resided at the Clinical Research Center for 3.5 d of baseline testing while consuming energy-balanced diets containing 55% E complex carbohydrate. For 12 outpatient days, they consumed usual ad libitum diets along with three servings per day of glucose, fructose, or HFCS-sweetened beverages (n = 16/group), which provided 25% E requirements. Subjects then consumed energy-balanced diets containing 25% E sugar-sweetened beverages/30% E complex carbohydrate during 3.5 d of inpatient intervention testing.Main Outcome Measures: Twenty-four-hour triglyceride area under the curve, fasting plasma low-density lipoprotein (LDL), and apolipoprotein B (apoB) concentrations were measured.Results: Twenty-four-hour triglyceride area under the curve was increased compared with baseline during consumption of fructose (+4.7 +/- 1.2 mmol/liter x 24 h, P = 0.0032) and HFCS (+1.8 +/- 1.4 mmol/liter x 24 h, P = 0.035) but not glucose (-1.9 +/- 0.9 mmol/liter x 24 h, P = 0.14). Fasting LDL and apoB concentrations were increased during consumption of fructose (LDL: +0.29 +/- 0.082 mmol/liter, P = 0.0023; apoB: +0.093 +/- 0.022 g/liter, P = 0.0005) and HFCS (LDL: +0.42 +/- 0.11 mmol/liter, P < 0.0001; apoB: +0.12 +/- 0.031 g/liter, P < 0.0001) but not glucose (LDL: +0.012 +/- 0.071 mmol/liter, P = 0.86; apoB: +0.0097 +/- 0.019 g/liter, P = 0.90).Conclusions: Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults. (J Clin Endocrinol Metab 96: E1596-E1605, 2011)