Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
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DOI：
10.1016/j.isci.2020.101386
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发表时间：
2020-08-21
期刊：
影响因子：
5.8
通讯作者：
Kim, Jhingook
中科院分区：
文献类型：
--
作者：
Kim, Hong Kwan;Joung, Je-Gun;Kim, Jhingook
对临床同质的早期从不吸烟的肺腺癌女性患者进行外显子组和转录组分析，以了解肿瘤-T细胞相互作用和免疫逃逸点。使用我们在癌症免疫周期中的八个功能类别的新基因组，通过两个主要结构域中的缺陷基因表达，在该免疫检查点阻断难治性队列中鉴定了三个不同的亚组，即，I型干扰素产生/信号传导途径和抗原呈递机制。我们的方法可以在理解免疫逃避机制，开发有效选择罕见免疫检查点阻断应答的方法以及寻找新的治疗策略方面发挥关键作用。
Exome and transcriptome analyses of clinically homogeneous early-stage never -smoker female patients with lung adenocarcinoma were performed to under-stand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, devel-oping a method for effective selection of rare immune checkpoint blockade re-sponders, and finding new treatment strategies.