DEVELOPMENTAL STUDIES AND CLINICAL-APPLICATION OF MISMATCH NEGATIVITY - PROBLEMS AND PROSPECTS
DEVELOPMENTAL STUDIES AND CLINICAL-APPLICATION OF MISMATCH NEGATIVITY - PROBLEMS AND PROSPECTS
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DOI：
10.1097/00003446-199502000-00008
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发表时间：
1995-02-01
期刊：
影响因子：
3.7
通讯作者：
FLIEGER, KZ
中科院分区：
文献类型：
--
作者：
KURTZBERG, D;VAUGHAN, HG;FLIEGER, KZ
失匹配负波（MMN）在临床上的应用，以评估个人的听觉能力是很难确定的，包括婴儿，幼儿和严重的认知障碍的辨别能力，有广泛的兴趣。在MMN可以被用作临床电生理测量之前，有必要确定它可以在正常个体中可靠地引出。本章描述了一个详细的分析MMN记录在一组健康的8岁儿童，以评估内主体和主体间的可靠性的反应。我们的结论是，虽然统计上可靠的结果，可以获得与组数据，甚至在个人时，可以提供大量的刺激，不利的信号噪声比的个人MMN数据目前限制了其临床应用。建议的方法来克服这些困难，其最终的临床实用性。
There is wide interest in the clinical application of mismatch negativity (MMN) to assess discriminative capabilities in individuals whose auditory capacities are difficult to determine, including infants, young children and those with severe cognitive impairment. Before MMN can be used as a clinical electrophysiologic measure, it is necessary to establish that it can be reliably elicited in normal individuals. This chapter describes a detailed analysis of MMN recorded in a group of healthy 8-yr-old children to assess intrasubject and intersubject reliability of the response. We conclude that although statistically reliable results can be obtained with group data, and perhaps even in individuals when large numbers of stimuli can be delivered, the unfavorable signal to noise ratio of individual MMN data currently limits its clinical applicability. Suggestions for approaches to surmount these difficulties are presented for its eventual clinical usefulness.