Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells
Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells
复制标题
冬凌草甲素诱导SW620人结直肠腺癌细胞凋亡
DOI：
10.3892/ol.2011.408
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发表时间：
2011-11-01
期刊：
影响因子：
2.9
通讯作者：
Pan, Yingjie
中科院分区：
文献类型：
--
作者：
Ji, Zhe;Tang, Qingjiu;Pan, Yingjie
冬凌草素是一种从冬凌草中分离得到的二萜类化合物。原，抑制人肿瘤细胞系SW620（结肠）、MCF-7（乳腺）和K562（骨髓）的生长，并诱导SW620中显著水平的凋亡。在暴露于冬凌草苷24小时后，观察到细胞凋亡的形态学变化。生长抑制与G1期阻滞有关，并且随着时间和剂量的增加，caspase-3活性增加。因此，我们得出结论，oriidonin通过激活caspase-3诱导细胞凋亡，从而抑制SW620细胞的增殖。我们的数据表明，oridonin作为一种抗结直肠腺癌的药物可能具有显著的潜力。
Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, inhibited the growth of human tumor cell lines SW620 (colon), MCF-7 (breast) and K562 (bone marrow), and induced significant levels of apoptosis in SW620. Morphological changes indicative of cell apoptosis were observed after the cells were exposed to oridonin for 24 h. Growth inhibition was associated with G1 phase arrest, and with time- and dose-dependent increases in caspase-3 activity. We therefore conclude that oridonin inhibits the proliferation of SW620 cells by induction of apoptosis via the activation of caspase-3. Our data suggest that oridonin may have significant potential as an anti-colorectal adenocarcinoma agent.