Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic olig2-expressing precursors
Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic olig2-expressing precursors
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DOI：
10.1523/jneurosci.1807-07.2007
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发表时间：
2007-07-18
影响因子：
5.3
通讯作者：
Fishell, Gord
中科院分区：
文献类型：
--
作者：
Miyoshi, Goichi;Butt, Simon J. B.;Fishell, Gord
小鼠新皮质的抑制性 GABA 能中间神经元是一个高度异质的神经元群体，起源于腹侧端脑，切向向上迁移到发育中的皮质板。大多数皮质中间神经元源自称为内侧神经节隆起（MGE）的短暂胚胎结构，但如何在该区域中指定显着的多样性尚不清楚。我们采取了遗传命运图谱策略来阐明 MGE 内皮质中间神经元亚型的时间起源。我们使用了受 Olig2 调节的 Cre 的诱导形式，Olig2 是一种在 MGE 神经祖细胞中高度表达的基本螺旋-环-螺旋转录因子。我们观察到，皮质中间神经元的生理亚型在很大程度上因其生成时间点而独特。
Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.