The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior
The Elevated Plus-Maze Test: Differential Psychopharmacology of Anxiety-Related Behavior
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DOI：
10.1177/1754073911421374
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发表时间：
2012-01-01
期刊：
影响因子：
5.4
通讯作者：
Ho, Ying-Jui
中科院分区：
文献类型：
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作者：
Pawlak, Cornelius R.;Karrenbauer, Britta D.;Ho, Ying-Jui
个体因素在行为神经科学中的作用是一个重要但仍然被忽视的研究领域。例如，高架十字迷宫测试是衡量啮齿动物无条件厌恶动机行为最常用的范例之一。然而，尽管进行了大量的这项测试实验，但评估高架十字迷宫和相关神经生物学功能的系统个体差异的努力却很少。本综述的目的首先是对该测试进行总体概述和介绍，其次是基于给定的未选择的大鼠群体中十字迷宫行为的自然变化的焦虑动物模型。最后，讨论了动物研究中此类方法的关键方面，并给出了下一步的建议。
The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and introduction about the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here.