Do (epi)genetics impact the brain in functional neurologic disorders?
Do (epi)genetics impact the brain in functional neurologic disorders?
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DOI：
10.1016/b978-0-12-801772-2.00014-x
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Frodl, T.
中科院分区：
文献类型：
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作者：
Frodl, T.
神经精神病学研究的进展应该会导致对功能性神经障碍及其诊断的理解的显着改善。然而，关于转换障碍和躯体形式障碍的表观遗传学和遗传学研究才刚刚开始。这篇综述展示了这一领域的现状，并试图弥合与其他精神疾病（如抑郁症）中基因-压力相互作用的已知差距。转换障碍的病因被假设为多因素。这些考虑也表明，潜在的病因因素导致脑功能的改变，无论是偶发性的还是慢性的，最终导致脑结构的变化。特别是，环境如何影响大脑结构和功能的知识，例如，通过表观遗传调控，可能是未来功能性神经障碍研究的兴趣。回顾文献结果的证据表明，童年逆境发挥作用的功能性神经障碍的发展，其中目前还没有报告存在关于童年逆境和遗传因素之间的相互作用或表观遗传学的影响。
Advances in neuropsychiatric research are supposed to lead to significant improvements in understanding functional neurologic disorders and their diagnosis. However, epigenetic and genetic research on conversion disorders and somatoform disorders is only at its start. This review demonstrates the current state within this field and tries to bridge a gap from what is known on gene - stress interactions in other psychiatric disorders like depression. The etiology of conversion disorders is hypothesized to be multifactorial. These considerations also suggest that potential etiologic factors lead to alterations in brain function, either episodically or chronically, eventually leading to structural brain changes. In particular, the knowledge of how the environment influences brain structure and function, e.g., via epigenetic regulation, may be interesting for future research in functional neurologic disorders. Reviewing the literature results in evidence that childhood adversities play a role in the development of functional neurologic disorders, whereby at present no reports exist about the interactive effect between childhood adversity and genetic factors or about the impact of epigenetics.