Effects of Ε11-Testolactone on the Pituitary-Testicular Axis In Oligospermic Men
Effects of Ε11-Testolactone on the Pituitary-Testicular Axis In Oligospermic Men
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Ε11-睾内酯对少精男性垂体-睾丸轴的影响
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
A. Glass
中科院分区：
文献类型：
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作者：
R. Vigersky;A. Glass
10例特发性少精子症患者接受E1睾丸内酯（Teslac）治疗，这是一种有效的雄激素向雌激素转化的抑制剂。Teslac治疗后血清雌二醇和雌酮水平分别下降34%（P < 0.01）和41%（P< 0.01），血清睾酮和雄烯二酮水平分别上升47%（P < 0.02）和70%（P < 0.01）。睾酮：雌二醇比值增加126%（23.5 ± 2.5 × HT（1）至45.2 ± 5.0 × 10-1; P < 0.01），雄烯二酮：雌酮比值增加231%（4.7 ± 0.6 × 10-1至12.9 ± 2.0 × 10-1; P< 0.01）。基础和LRH刺激的血清促性腺激素水平不受这些变化的影响。精子密度由10.8 ± 2.5 × 107 ml上升到19.8 ± 4.7 × 107 ml（P < 0.01），精子总数由26.8 ± 6.5 × 106上升到60.6 ± 14.3 × 106（P < 0.001）。活动力和精液量无显著变化。其中三个妻子怀孕了。Teslac给药无不良反应。这些数据表明，Teslac可能是治疗男性糖尿病的有效方法。
Ten men with idiopathic oligospermia were treated with E1testolactone (Teslac), a potent inhibitor of conversion of androgens to estrogens. Teslac therapy caused a fall i n serum estradiol and estrone levels of 34%(P < 0.01) and 41% (P< 0.01), respectively, and a rise in serum testosterone and androstenedione of 47% (p < 0.02) and 70%(P < 0.01), respectively. The testosterone:estradiol ratio increased by 126% (23.5 ± 2.5 × HT(1) to 45.2 ± 5.0 × 10-1; P < 0.01) and the androstene-dione:estrone ratio increased 231% (4.7 ± 0.6 × 10-1 to 12.9 ± 2.0 × 10-1; P< 0.01). Basal and LRH-stimulated serum gonadotro-pin levels were unaffected by these changes. Sperm density rose from 10.8 ± 2.5 to 19.8 ± 4.7 × 107ml (P < 0.01) and total sperm count from 26.8 ± 6.5 to 60.6 ± 14.3 × 106 (P < 0.001). There was no significant change in motility or semen volume. Three of the wives became pregnant. There were no adverse effects of Teslac administration. These data suggest that Teslac may be an effective treatment for men wit...