Could culicine mosquitoes transmit human malaria?
Could culicine mosquitoes transmit human malaria?
复制标题
蚊子会传播人类疟疾吗？
DOI：
10.1016/j.pt.2013.09.003
复制
发表时间：
2013
影响因子：
9.6
通讯作者：
Knöckel,Julia
中科院分区：
文献类型：
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作者：
Molina-Cruz,Alvaro;Lehmann,Tovi;Knöckel,Julia
众所周知，人类疟疾完全通过按蚊传播。库蚊，如伊蚊。和库拉克斯普。是包括病毒和丝虫在内的其他人类病原体的重要媒介，但从未观察到会传播哺乳动物疟疾。库蚊确实传播禽类疟疾，有趣的是，它允许哺乳动物感染的疟疾寄生虫的部分发展，这意味着蚊子的生理屏障阻止了寄生虫的传播。虽然机制(S)尚不清楚，但蚊子的免疫系统可能参与了消灭疟原虫的过程。然而，疟原虫已经显示出相当大的适应新媒介的能力，目前由人类引起的生态变化可能会促进人类感染的疟原虫适应库拉西林。这种事件可能会产生广泛的流行病学影响，因此值得关注。
Human malaria is known to be transmitted strictly by anopheline mosquitoes. Culicine mosquitoes such asAedesspp. andCulexspp. are important vectors of other human pathogens including viruses and filarial worms, but have never been observed to transmit mammalian malarias. Culicines do transmit avian malarias and, interestingly, allow partial development of mammalian-infectiousPlasmodiumparasites, implying that physiological barriers in the mosquitoes prevent parasite transmission. Although the mechanism(s) are not known, the mosquito immune system is probably involved in eliminatingPlasmodium. However,Plasmodiumhas shown substantial capacity to adapt to new vectors, and current ecological changes caused by humans could promote adaptation of human-infectiousPlasmodiumparasites to culicines. Such an event could have widespread epidemiological implications and therefore merits attention.