PREVENTION OF TRANSFUSION-ACQUIRED CYTOMEGALO-VIRUS INFECTION IN INFANTS BY BLOOD FILTRATION TO REMOVE LEUKOCYTES
PREVENTION OF TRANSFUSION-ACQUIRED CYTOMEGALO-VIRUS INFECTION IN INFANTS BY BLOOD FILTRATION TO REMOVE LEUKOCYTES
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DOI：
10.1016/s0140-6736(89)92330-1
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发表时间：
1989-06-03
期刊：
影响因子：
168.9
通讯作者：
JAMES, J
中科院分区：
文献类型：
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作者：
GILBERT, GL;HUDSON, IL;JAMES, J
进行了一项多中心对照试验，以确定通过“Imugard IG500”（Terumo）过滤器从血液中去除白细胞是否可以预防新生儿输血获得性巨细胞病毒（CMV）感染。对72名母亲血清反应阴性并接受了一些血清反应阳性血液的婴儿进行了为期6个月的CMV感染证据随访。接受过滤和未过滤血液的两组在中位妊娠、出生体重或血清阳性血液量方面无显著差异（中位体积分别为32.5 ml和34.5 ml）。接受未过滤血液的42名婴儿中有9名（21%）感染CMV，接受过滤血液的30名婴儿中无一例感染CMV。所有受感染的婴儿出生时体重均小于1500 g，占极低出生体重儿（VLBW）CMV感染风险的31%。24名极低出生体重婴儿谁收到过滤血清阳性血液感染。1例感染婴儿死亡，5例临床表现与CMV感染一致。结果表明，通过白细胞过滤器过滤血液可预防输血获得性CMV感染。这种方法优于其他去除白细胞的方法或仅使用新生儿血清阴性血液的方法。
A multicentre, controlled trial was carried out to determine whether removal of leucocytes from blood by means of ''Imugard IG500'' (Terumo) filters would prevent transfusion-acquired cytomegalovirus (CMV) infection in newborn infants. 72 infants whose mothers were seronegative and who received some seropositive blood were followed for 6 months for evidence of CMV infection. There were no significant differences between the groups who received filtered and unfiltered blood in median gesttion, birthweight, or amount of seropositive blood received (median volume 32.5 ml and 34.5 ml, respectively). 9 (21%) of the 42 infants who received unfiltered blood and none of the 30 who received filtered blood were infected with CMV. All infected infants weighted less than 1500 g at birth; they represented 31% of very low birthweight (VLBW) infants at risk of CMV infection. None of 24 VLBW infants who received filtered seropositive blood was infected. 1 infected infant died and 5 had clinical features consistent with CMV infection. The results show that transfusion-acquired CMV infection is preventable by filtration of blood through a leucocyte filter. This method has advantages over other methods of removing leucocytes or the use of only seronegative blood for newborn infants.