The expanding world of extracellular traps: not only neutrophils but much more.
The expanding world of extracellular traps: not only neutrophils but much more.
复制标题
细胞外陷阱的扩展世界：不仅中性粒细胞，而且更多。
DOI：
10.3389/fimmu.2012.00420
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Medina E
中科院分区：
文献类型：
--
作者：
Goldmann O;Medina E
细胞外陷阱的释放是最近描述的对感染的先天免疫应答机制。尽管在嗜中性粒细胞抗菌效应机制的背景下已经深入地研究了这些结构，但其他免疫细胞如肥大细胞、嗜酸性粒细胞和巨噬细胞也可以释放这些结构。不同的DNA有几个共同的特征，无论它们起源于什么类型的细胞，包括嵌入抗菌肽，蛋白酶和组蛋白的DNA骨架。然而，它们也表现出显着的个体差异，例如DNA骨架来源的亚细胞区室的类型（例如，细胞核或线粒体）、池内响应细胞的比例和/或细胞形成的分子机制。这篇综述总结了近年来积累的知识，关于复杂和不断扩大的世界，特别强调其他免疫细胞的作用，而不是专门对中性粒细胞在免疫功能中的作用。
The release of extracellular traps (ETs) is a recently described mechanism of innate immune response to infection. Although ETs have been intensely investigated in the context of neutrophil antimicrobial effector mechanisms, other immune cells such as mast cells, eosinophils, and macrophages can also release these structures. The different ETs have several features in common, regardless of the type of cells from which they originated, including a DNA backbone with embedded antimicrobial peptides, proteases, and histones. However, they also exhibit remarkable individual differences such as the type of sub-cellular compartments from where the DNA backbone originates (e.g., nucleus or mitochondria), the proportion of responding cells within the pool, and/or the molecular mechanism/s underlying the ETs formation. This review summarizes the knowledge accumulated in recent years regarding the complex and expanding world of ETs and their role in immune function with particular emphasis on the role of other immune cells rather than on neutrophils exclusively.