Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway
Clinical significance of SLP-2 in epithelial ovarian cancer and its regulatory effect on the Notch signaling pathway
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DOI：
10.26355/eurrev_202002_20340
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发表时间：
2020-02-01
影响因子：
3.3
通讯作者：
Guo, H-M
中科院分区：
文献类型：
--
作者：
Guo, X-Y;Guo, H-F;Guo, H-M
目的：探讨Stomatin-like protein 2 （SLP-2）在上皮性卵巢癌（EOC）中的表达及其临床意义。患者和方法：采用实时定量聚合酶链反应（qRT-PCR）检测SLP-2在EOC组织和细胞系中的差异表达。分析SLP-2表达与EOC患者临床病理资料的关系。结果：QRT-PCR结果显示，与正常对照相比，SLP-2在EOC组织和EOC细胞中均表达上调。SLP-2表达与肿瘤病理分级相关。远处转移和肿瘤分期。下调SLP-2可通过激活Notch信号通路，显著抑制EOC细胞增殖，促进细胞凋亡。SLP-2的下调可显著下调Notch1和Hes1。结论：SLP-2是参与EOC进展的新因子，可作为EOC患者潜在的生物标志物和治疗靶点。
OBJECTIVE: To explore the expression of Stomatin-like protein 2 (SLP-2) and its clinical significance in epithelial ovarian cancer (EOC).PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the differential expression of SLP-2 in EOC tissues and cell lines. The relationship between SLP-2 expression and clinical pathological data of EOC patients was analyzed.RESULTS: QRT-PCR results suggested that the SLP-2 was up-regulated in both EOC tissues and EOC cells by comparing with normal control. SLP-2 expression was a correlation with tumor pathological grade. distant metastasis, and TNM stage in EOC patients. Down-regulation of SLP-2 could significantly inhibit proliferation and promote apoptosis of EOC cells by activating the Notch signaling pathway. Knockdown of SLP-2 markedly downregulated Notch1 and Hes1.CONCLUSIONS: SLP-2 was a novel factor involved in EOC progression, and could be utilized as a potential biomarker and therapeutic target for the EOC patients.