The use of platelet rich plasma, bone morphogenetic protein-2 and different scaffolds in oral and maxillofacial surgery - literature review in comparison with own clinical experience.
The use of platelet rich plasma, bone morphogenetic protein-2 and different scaffolds in oral and maxillofacial surgery - literature review in comparison with own clinical experience.
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DOI：
10.5037/jomr.2011.2102
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Osadnik M
中科院分区：
文献类型：
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作者：
Schuckert KH;Jopp S;Osadnik M
本文旨在通过相关文献和自身临床经验，对富血小板血浆、重组人骨形态发生蛋白-2和不同支架材料（即磷酸三钙、聚己内酯、脱钙骨基质和无机牛骨矿物质）在口腔颌面外科中的应用进行回顾和评价。使用MEDLINE、MEDPILOT和科克伦药理学综述数据库进行文献综述。它侧重于过去五年（2006-2010年）出版的手稿和综述。采用的关键术语是富含血小板的血浆、骨形态发生蛋白及其与上述支架的组合。特别强调了临床研究和动物试验的结果。将文献中的陈述与作者自己的临床数据进行比较。新的出版物和综述证明了富血小板血浆在骨再生中的优势。对文献综述的结果进行了讨论，并与详细介绍作者自身经验的出版物进行了比较。根据临床病例，在最佳基质（含或不含重组人骨形态发生蛋白-2）的基础上，结合富含血小板的血浆，获得了关于新生长骨的有利结果。因此，从自体骨移植到骨组织工程的范式转变似乎是有希望的。
The purpose of this article was to review and critically assess the use of platelet rich plasma, recombinant human bone morphogenetic protein-2 and different scaffolds (i.e. tricalciumphosphate, polycaprolactone, demineralized bone matrix and anorganic bovine bone mineral) in oral and maxillofacial surgery comparing the relevant literature and own clinical experience. A literature review was conducted using MEDLINE, MEDPILOT and COCHRANE DATABASE OF SYSTEMATIC REVIEWS. It concentrated on manuscripts and overviews published in the last five years (2006-2010). The key terms employed were platelet rich plasma, bone morphogenetic proteins and their combinations with the above mentioned scaffolds. The results of clinical studies and animal trials were especially emphasized. The statements from the literature were compared with authors’ own clinical data. New publications and overviews demonstrate the advantages of platelet rich plasma in bone regeneration. The results from the literature review were discussed and compared with the publications detailing authors' own experiences. A favourable outcome concerning newly grown bone was achieved combining platelet rich plasma in addition to optimal matrices with or without recombinant human bone morphogenetic protein-2, depending on the clinical case. As a consequence, the paradigm shift from transplantation of autogenous bone to bone tissue engineering appears promising.