Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction.
Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction.
复制标题
DOI：
10.1007/s11481-011-9278-3
复制
发表时间：
2011-12
影响因子：
6.2
通讯作者：
Meucci, Olimpia
中科院分区：
文献类型：
--
作者：
Abt, Anna Cook;Meucci, Olimpia
铁蛋白重链亚基（FHC）是一种普遍存在的蛋白，以其作为铁蛋白复合物的一部分的铁隔离活性而闻名，最近被描述为一种通过趋化因子受体CXCR4信号传导的新型抑制剂。FHC水平及其对CXCR4激活的影响在暴露于mu-阿片受体激动剂（如吗啡）的皮质神经元中增加，这种影响可能是神经元特有的。成熟大脑中CXCR4信号的主要作用包括促进神经发生、激活促存活信号和调节兴奋毒性通路；因此，FHC上调可能导致与阿片类药物滥用相关的神经元功能障碍。本文综述了我们对神经元CXCR4的功能、阿片类药物对其的调控、FHC在这一过程中的作用以及FHC产生的已知机制的了解。我们推测了阿片类药物调控FHC的机制，并提出FHC作为阿片类药物诱导神经病理学的新靶点。
The heavy chain subunit of ferritin (FHC), a ubiquitous protein best known for its iron-sequestering activity as part of the ferritin complex, has recently been described as a novel inhibitor of signaling through the chemokine receptor CXCR4. Levels of FHC as well as its effects on CXCR4 activation increase in cortical neurons exposed to mu-opioid receptor agonists such as morphine, an effect likely specific to neurons. Major actions of CXCR4 signaling in the mature brain include a promotion of neurogenesis, activation of pro-survival signals, and modulation of excitotoxic pathways; thus FHC up-regulation may contribute to the neuronal dysfunction often associated with opiate drug abuse. This review summarizes our knowledge of neuronal CXCR4 function, its regulation by opiates and the role of FHC in this process, and known mechanisms controlling FHC production. We speculate on the mechanism involved in FHC regulation by opiates, and offer FHC as a new target in opioid-induced neuropathology.
登录
查看更多内容
影响因子：
5
作者：
Chen, CG;Li, J;Liu-Chen, LY
通讯作者：
Liu-Chen, LY
影响因子：
5.3
作者：
Chalasani, SH;Sabelko, KA;Raper, JA
通讯作者：
Raper, JA
影响因子：
4.8
作者：
Cairo, G;Castrusini, E;BernelliZazzera, A
通讯作者：
BernelliZazzera, A
影响因子：
4.8
作者：
GUO, B;PHILLIPS, JD;LEIBOLD, EA
通讯作者：
LEIBOLD, EA
DOI：
10.1111/j.1460-9568.2010.07402.x
发表时间：
2010-10
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Burbassi S;Sengupta R;Meucci O
通讯作者：
Meucci O