Is there a role for chemotherapy and radiation in the treatment of patients with low-grade myofibroblastic sarcoma?
Is there a role for chemotherapy and radiation in the treatment of patients with low-grade myofibroblastic sarcoma?
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化疗和放疗在治疗低度恶性肌纤维母细胞肉瘤患者中是否有效？
DOI：
10.1007/s12094-020-02425-4
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发表时间：
2020-06-30
影响因子：
3.4
通讯作者：
Zhang, C.
中科院分区：
文献类型：
--
作者：
Xu, Y.;Xu, G.;Zhang, C.
目的：低级别肌纤维母细胞肉瘤（LGMS）是一种罕见的肿瘤，多发生于头颈部。对于LGMS患者仍然没有最佳的治疗策略。我们回顾性研究了化疗和放疗对LGMS患者的疗效。方法/患者我们从监测、流行病学和最终结果（SEER）数据库中获取了2001年至2015年期间96例被诊断为LGMS的患者的数据。我们使用Kaplan-Meier曲线和log-rank检验来估计总生存率（OS），并使用Cox比例风险回归来确定预后因素。结果患者中位年龄为55.0岁。22例患者头颈部有LGMS。96例患者中，手术治疗86例（89.6%），放疗28例（29.2%），化疗20例（10.4%）。平均OS为125.2[95%置信区间（CI） 106.3-144.2]个月。1、3、5、10年生存率分别为88%、77%、70%、59%。年龄大于60岁、淋巴结呈阳性、未接受手术治疗是LGMS患者的独立预后因素，而化疗和放疗则不是。结论手术切除是治疗LGMS最有效的方法。化疗和放疗对LGMS患者的生存改善作用有限。因此，化疗和/或放疗不应常规应用于LGMS，特别是那些术后切缘阴性的患者。
PurposeLow-grade myofibroblastic sarcoma (LGMS) is a rare entity with a predilection for the head and neck. There are still no optimal treatment strategies for patients with LGMS. We retrospectively investigated the efficacies of chemotherapy and radiation treatment for patients with LGMS.Methods/patientsWe obtained data from the Surveillance, Epidemiology, and End Result (SEER) database for 96 patients diagnosed with LGMS between 2001 and 2015. We used Kaplan–Meier curves and log-rank tests to estimate overall survival (OS) and Cox proportional hazard regression to identify prognostic factors.ResultsThe median age of the patients was 55.0 years. Twenty-two of the patients had LGMS in the head and neck region. Of the 96 patients, 86 (89.6%) received surgical treatment, 28 (29.2%) received radiation treatment, and 20 (10.4%) received chemotherapy. The mean OS was 125.2 [95% confidence interval (CI) 106.3–144.2] months. The 1, 3, 5, and 10-year OS rates were 88%, 77%, 70%, and 59%, respectively. Age greater than 60 years, positive nodal status, and no surgical treatment were independent prognostic factors for patients with LGMS, whereas chemotherapy and radiation treatment were not.ConclusionsSurgical resection is the most effective therapy for LGMS. Chemotherapy and radiation had limited effects on survival improvement for patients with LGMS. Therefore, chemotherapy and/or radiation therapy should not be routinely performed in LGMS, especially for those with negative margins after surgery.