Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women
Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women
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DOI：
10.1093/oxfordjournals.aje.a008905
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发表时间：
1996-07-15
影响因子：
5
通讯作者：
Folsom, AR
中科院分区：
文献类型：
--
作者：
Zheng, W;Doyle, TJ;Folsom, AR
茶一直被证明可以抑制实验动物肿瘤的发生。然而，对人类有益的证据是有限的，作者在一项对35,369名绝经后爱荷华州妇女的前瞻性队列研究中研究了非草药茶消费与癌症发病率之间的关系。在这个队列中，通过1986年的邮寄调查收集了饮茶频率和其他饮食和生活方式因素的信息。经过8年的随访，通过爱荷华州的国家卫生登记处在这个队列中确定了2,936例非皮肤癌病例，比例风险回归被用来获得调整后的相对风险和95%的置信区间之间的关联茶消费和癌症发病率，在控制了混杂因素后，作者发现，经常喝茶与所有癌症的发病率略有下降有关，但没有统计学意义，在消化道癌症（p趋势，0.04）和泌尿道癌症（p趋势，0.02）中观察到饮茶频率增加的负相关性。与从不喝茶或偶尔喝茶的女性相比，每天喝茶超过或等于2杯（474英里）的女性患消化道癌症的相对风险为0.68（95%置信区间（CI）0.47-0.98），泌尿道癌为0.40（95%CI 0.16-0.98），尽管特定部位分析无统计学显著性，但在特定消化道和泌尿道癌症中观察到类似的负相关，未发现饮茶与黑色素瘤的明显相关性，非霍奇金淋巴瘤，或胰腺癌、肺癌、乳腺癌、子宫体癌或卵巢癌。这项研究表明，茶是世界上最受欢迎的饮料之一，可以预防绝经后妇女的某些癌症。
Tea has consistently been shown to inhibit the occurrence of tumors in experimental animals. The evidence for such a beneficial effect in humans, however, is limited, The authors examined the association between non-herbal tea consumption and cancer incidence in a prospective cohort study of 35,369 postmenopausal Iowa women. In this cohort, information on the frequency of tea drinking and other dietary and lifestyle factors was collected by mailed survey in 1986, After 8 years of follow-up, 2,936 incident non-skin cancer cases were ascertained in this cohort through the State Health Registry of Iowa, Proportional hazards regressions were used to derive adjusted relative risks and 95% confidence intervals for the association between tea consumption and cancer incidence, After controlling for confounding factors, the authors found that regular tea consumption was related to a slight, but not statistically significant, reduced incidence of all cancers combined, Inverse associations with increasing frequency of tea drinking were seen for cancers of the digestive tract (p for trend, 0.04) and the urinary tract (p for trend, 0.02). For women who reported drinking greater than or equal to 2 cups (474 mi) of tea per day, compared with those who never or occasionally drank tea, the relative risk for digestive tract cancers was 0.68 (95% confidence interval (CI) 0.47-0.98) and for urinary tract cancers, 0.40 (95% CI 0.16-0.98), Similar inverse associations were seen for specific digestive and urinary tract cancers, although site-specific analyses were not statistically significant, No appreciable association of tea drinking was found with melanoma, non-Hodgkin's lymphoma, or cancers of the pancreas, lung, breast, uterine corpus, or ovary. This study suggests that tea, one of the most popular beverages consumed worldwide, may protect against some cancers in postmenopausal women.