Spine-type densities of hippocampal CA1 neurons vary in proestrus and estrus rats
Spine-type densities of hippocampal CA1 neurons vary in proestrus and estrus rats
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DOI：
10.1016/j.neulet.2004.12.043
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发表时间：
2005-04-29
影响因子：
2.5
通讯作者：
Cervantes, M
中科院分区：
文献类型：
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作者：
González-Burgos, I;Alejandre-Gómez, M;Cervantes, M
棘介导的突触活动与学习能力有关。据报道，动情前期大鼠海马CA 1区锥体神经元的树突棘比动情期动物的树突棘多，但一些行为学研究报道，在动情周期的动情期阶段，树突棘的表现更好。由于棘的形状已被证明是强烈相关的突触后处理的信息，定量形态学研究有关的比例密度的每种类型的棘，进行了在高尔基体材料的海马CA 1锥体细胞的发情前期和发情大鼠。在确定了三个规律的发情周期后，使用了7只处于发情前期的Sprague-Dawley雌性成年大鼠和8只处于发情期的雌性成年大鼠。海马锥体细胞的蘑菇状棘在发情前期大鼠中占主导地位，在这个阶段比发情期多15.1%;而薄棘是发情期动物中主要的棘类型，在发情期比发情前期多15.5%。在大鼠动情周期的各个阶段，海马CA 1区锥体神经元的蘑菇形或薄棘的优势，可能与海马活动依赖的记忆信息的组织。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
Spines-mediated synaptic activity has been associated to learning ability. Dendritic spines from hippocampal CA1 pyramidal neurons of proestrus rats have been reported to be more numerous than in estrus animals, but some behavioral studies have reported a better performance during the estrus stage of the estrous cycle. Because spine shape has been shown to be strongly related to the post-synaptic processing of information, a quantitative morphological study related to the proportional density of each type of spine, was conducted in Golgi material of hippocampal CA1 pyramidal cells of proestrus and estrus rats. After three regular estrous cycles had been asserted, seven Sprague-Dawley female adult rats in proestrus and eight in estrus, were used. Mushroom-shaped spines from hippocampal pyramidal cells predominated in proestrous rats, being 15.1% more numerous in this stage than in estrus; while thin spines were the predominant type of spine in estrous animals, being 15.5% more abundant in estrus than in proestrus. The predominance of the mushroom-shaped or thin spines in the hippocampal CA1 pyramidal neurons during the respective stages of the rat estrous cycle, could be related to the organization of the hippocampal activity-dependent mnemonic information. (c) 2004 Elsevier Ireland Ltd. All rights reserved.