SERUM-γ-GLUTAMYLTRANSFERASE IN SCREENING AND CONTINUOUS CONTROL OF HEAVY DRINKING IN MIDDLE-AGED MEN
SERUM-γ-GLUTAMYLTRANSFERASE IN SCREENING AND CONTINUOUS CONTROL OF HEAVY DRINKING IN MIDDLE-AGED MEN
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血清-γ-谷氨酰转移酶在中年男性酗酒筛查和持续控制中的应用
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
B. Hood
中科院分区：
文献类型：
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作者：
H. Kristenson;E. Trell;B. Hood
在马尔默正在进行的一项人口研究中，血清-谷氨酰转移酶（GGT）被用于高饮酒量的生化筛查，并作为进一步调查、治疗和控制分布中前十分位筛查GGT的中年男性的工具。为此目的，设立了一个特别门诊诊所，本报告对此作了说明。报告了首批6760名中年男性筛查参与者干预组的组成和方案的可行性。在前十分之一的GGT筛查个体中，随机抽取一半的个体分配到干预组，在初步退出和排除并发疾病后，干预组由252人组成，他们现在已经被跟踪了3到6年。在结构化访谈的基础上，得出结论，76%的人存在危险水平的酒精消费。虽然四分之一的人退出了干预计划，但结果表明，为在一般健康筛查检查中发现GGT水平升高的个人设立门诊诊所是可行的，保留大多数人在门诊诊所，并考虑酒精习惯和消费水平与实验室测试值和一般身体健康状况的关系。
In an on-going population study in Malmo, serum-gamma-glutamyltransferase (GGT) is utilized both in biochemical screening of high alcohol consumption and as a tool in further investigation, treatment and control of middle-aged men with screening GGT in the top decile of the distribution. For this purpose, a special outpatient clinic has been instituted and is described in the present report. The composition of the intervention group and the feasibility of the program are reported for the first 6760 middle-aged male screening participants. A random one-half of the individuals with screening GGT in the top decile were allocated to the intervention group, which after primary dropouts and exclusion of concurrent diseases consisted of 252 individuals who have now been followed between three to six years. On the basis of structured interviews, hazardous levels of alcohol consumption were concluded to be present in 76% of the group. Although one-quarter of the group dropped out of the intervention program, the results indicate that it is feasible to institute an outpatient clinic for individuals with increased GGT levels found in a general health screening examination, to retain most individuals in this outpatient clinic and to consider alcohol habits and consumption levels in relation to the laboratory test value and general physical health status.