APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals.
APOE Genotype Affects Cognitive Training Response in Healthy Shanghai Community-Dwelling Elderly Individuals.
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APOE 基因型影响上海健康社区老年人的认知训练反应
DOI：
10.3233/jad-150039
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Li C
中科院分区：
文献类型：
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作者：
Feng W;Yokoyama JS;Yu S;Chen Y;Cheng Y;Bonham LW;Wang D;Shen Y;Wu W;Li C
认知训练可能有助于健康老年人维持认知功能的能力。基因型是否会改变训练效果仍不清楚。评估APOE对参与多领域认知训练的社区老年人随着时间的推移认知功能的影响。从上海一个城市社区筛选≥70岁的健康个体。145名健康中国老年人符合纳入标准，并被分配到干预组（n = 88）或对照组（n = 57）。多领域认知训练涉及24个不同内容的课程，为期12周。在基线、训练后立即、干预后6个月和12个月进行神经心理学测试;通过因素分析确定认知功能的复合指标。三个因素解释了功能的大部分变化（文字记忆，处理速度，执行功能）。干预减弱了12个月的处理速度下降，无论APOE基因型（p = 0.047）。APOE ε4携带者的执行功能在12个月内下降，与干预无关（p = 0.056）。12个月后存在显著的相互作用，其中干预ε4携带者的处理速度优于ε4对照（p = 0.003）。干预ε2携带者在训练后立即具有更好的执行功能（p = 0.02），并且在干预后6个月具有更好的言语记忆（p = 0.04）。这些影响仍然显着错误发现率校正后。多领域认知训练可以减少处理速度随时间的下降。随着时间的推移，APOE ε4与执行功能的下降有关，训练可以减轻ε4相关的处理速度下降。APOE ε2携带者也可以从训练中受益，特别是在执行功能和言语记忆方面。
Cognitive training may contribute to the ability to maintain cognitive function in healthy elderly adults. Whether genotype modifies training effects remains unknown. Assess influence of APOE on cognitive function over time in community-dwelling elderly adults participating in multi-domain cognitive training. Healthy individuals ≥70 years of age were screened from one urban community in Shanghai. 145 healthy Chinese older adults met inclusion criteria and were assigned to intervention (n = 88) or control (n = 57) groups. Multi-domain cognitive training involved 24 sessions of different content taking place over 12 weeks. Neuropsychological testing was administered at baseline, immediately after training, six months and twelve months post-intervention; composite measures of cognitive function were identified via factor analysis. Three factors explained the majority of variance in function (verbal memory, processing speed, executive function). The intervention attenuated 12-month declines in processing speed, regardless of APOE genotype (p = 0.047). Executive function declined in APOE ε4 carriers over 12 months, regardless of intervention (p = 0.056). There was a significant interaction after 12 months where intervention ε4 carriers had better processing speed than ε4 controls (p = 0.003). Intervention ε2 carriers had better executive function immediately after training (p = 0.02) and had better verbal memory 6-months post-intervention (p = 0.04). These effects remained significant after false-discovery rate correction. Multi-domain cognitive training reduces declines in processing speed over time. APOE ε4 is associated with reductions in executive function over time, and training may attenuate ε4-associated declines in processing speed. APOE ε2 carriers may also benefit from training, particularly on measures of executive function and verbal memory.