Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies
Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies
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DOI：
10.1002/gps.4780
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发表时间：
2018-02-01
影响因子：
4
通讯作者：
Guan, Xihong
中科院分区：
文献类型：
--
作者：
Dong, Yonghai;Chen, Xiaodan;Guan, Xihong
目的：低血清维生素E是否会增加老年人阿尔茨海默病（AD）的风险尚不明确。本荟萃分析旨在综合循证病例对照研究，以评估血清维生素E与AD风险之间的关系。方法通过PubMed、Embase、万方、重庆维普和中国国家知识基础设施数据库，在文章标题、摘要和关键词中使用核心术语维生素E/ α -生育酚和阿尔茨海默病/老年性痴呆/AD，筛选有相关研究。采用随机效应模型，采用加权平均差（WMD）和95%置信区间估计血清维生素E水平与AD的相关性。采用Cochran Q检验和I-2统计量评估异质性。采用森林图以图形方式显示meta分析结果。采用漏斗图和Egger检验评价发表偏倚。结果我们确定了17项符合入选标准的研究。研究包括2057名受试者，904名AD患者和1153名对照。结果表明，老年AD患者血清维生素E浓度低于健康对照组(WMD=-6.811mol/L， 95%可信区间为-8.998 ~ -4.625；Z=-6.105， P
ObjectiveWhether low-serum vitamin E increases the risk of Alzheimer disease (AD) in older people remains inconclusive. This meta-analysis aims to synthesize evidence-based case-control studies to evaluate the association between serum vitamin E and the risk of AD.MethodsPotentially relevant studies were selected through PubMed, Embase, Wanfang, Chongqing VIP, and China National Knowledge Infrastructure databases by using the core terms Vitamin E/alpha-tocopherol and Alzheime's disease/senile dementia/AD in the titles, abstracts, and keywords of the articles. The association between serum vitamin E levels and AD was estimated by using the weighted mean difference (WMD) and 95% confidence interval by adopting a random effects model. Heterogeneity was assessed by using Cochran Q test and I-2 statistic. Forest plot was used to present the results graphically from meta-analysis. Publication bias was evaluated by using funnel plots and Egger test.ResultsWe identified 17 studies that met the eligibility criteria. The studies included 2057 subjects with 904 AD patients and 1153 controls. The results indicated that AD patients had a lower concentration of serum vitamin E compared with healthy controls among older people (WMD=-6.811mol/L, 95% confidence interval -8.998 to -4.625; Z=-6.105, P