Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome
Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome
复制标题
2020 年维尔纳综合征管理指南。 2. 与维尔纳综合征相关的肌肉减少症
DOI：
10.1111/ggi.14076
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发表时间：
2020
影响因子：
3.3
通讯作者：
Yokote Koutaro
中科院分区：
文献类型：
--
作者：
Kuzuya Masafumi;Takemoto Minoru;Kubota Yoshitaka;Taniguchi Toshibumi;Motegi Sei‐Ichiro;Taniguchi Akira;Nakagami Hironori;Maezawa Yoshiro;Koshizaka Masaya;Kato Hisaya;Mori Seijiro;Tsukamoto Kazuhisa;Yokote Koutaro
AimSarcopenia被定义为一种将骨骼肌量减少与虚弱或身体功能下降结合在一起的情况。众所周知，在老年人中，骨骼减少的存在是虚弱、摔倒和身体功能障碍的风险。Werner综合征患者以内脏脂肪堆积、四肢纤细为特征，但有关Werner综合征患者骨质疏松症的发生率未见报道。我们还分析了7名Werner综合征患者的数据。结果关于Werner综合征与骨骼肌关系的文献搜索只有一篇来自日本的报道。根据这篇论文，在所调查的所有9个Werner综合征中，都观察到骨骼肌质量(附件骨骼肌指数)的减少。另一方面，在7例Werner综合征患者中，除1例男性患者继续进行阻力运动外，其余患者的附件骨骼肌指数均低于标准值。然而，抵抗运动可能会预防骨质疏松症的出现，并需要对Werner综合征患者进行早期干预。Geriatr Gerontol Int 2021；21：139-141。
AimSarcopenia is defined as a condition that combines decreased skeletal muscle mass with weakness or decreased physical function. It is well known that in older adults, the presence of sarcopenia is a risk of frailty, falls and physical dysfunction. Patients with Werner syndrome are characterized by visceral fat accumulation and thin limbs, but the prevalence of sarcopenia in patients with Werner syndrome has not been investigated.MethodsA literature search was conducted using Werner syndrome and skeletal muscle as keywords. We also analyzed data from our 7 Werner syndrome patients.ResultsA literature search on the relationship between Werner syndrome and skeletal muscle yielded only one article reported from Japan. According to this paper, a decrease in skeletal muscle mass (appendicular skeletal muscle index) was observed in all 9 Werner syndromes investigated. On the other hand, in our 7 Werner syndrome patients, their appendicular skeletal muscle indexes were below the standard value except for one male patient who had continued resistance exercise.ConclusionThe decrease in skeletal muscle mass frequently occurs in patients with Werner syndrome. However, resistance exercise may prevent the appearance of sarcopenia and requires early intervention in patients with Werner syndrome.Geriatr Gerontol Int 2021; 21: 139–141.