Normal Variation in Early Parental Sensitivity Predicts Child Structural Brain Development
Normal Variation in Early Parental Sensitivity Predicts Child Structural Brain Development
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DOI：
10.1016/j.jaac.2015.07.009
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发表时间：
2015-10-01
影响因子：
13.3
通讯作者：
Tiemeier, Henning
中科院分区：
文献类型：
--
作者：
Kok, Rianne;Thijssen, Sandra;Tiemeier, Henning
目的：早期护理会对儿童的大脑结构和功能产生影响。极端照顾经历的影响已经得到证实，但关于养育质量正常变化影响的研究却很少。此外，迄今为止还没有研究包括母亲和父亲的敏感性在儿童大脑成熟中的作用。本研究探讨了儿童早期母亲和父亲的敏感照顾与儿童后期大脑结构之间的前瞻性关系。方法：参与者被纳入基于人群的产前队列。在 191 个家庭中，在孩子 1 岁至 4 岁时反复观察母亲和父亲的敏感性。在 6 周时评估头围，并在 8 岁时使用磁共振成像 (MRI) 测量来评估大脑结构。 结果：在控制婴儿头部尺寸的情况下，幼儿期父母敏感性水平较高与 8 岁时较大的总脑容量（调整后的 beta = 0.15，p =.01）和灰质体积（调整后的 beta = 0.16，p =.01）相关。幼儿时期较高水平的母亲敏感性与 8 岁时较大的灰质体积相关（调整后的 beta = 0.13，p = 0.04），与婴儿头围无关。与母亲和父亲敏感性的关联没有显着差异。结论：护理质量的正常变化与儿童更优化的大脑发育的标志相关。研究结果说明了母亲和父亲在儿童大脑发育中的重要作用。
Objective: Early caregiving can have an impact on brain structure and function in children. The influence of extreme caregiving experiences has been demonstrated, but studies on the influence of normal variation in parenting quality are scarce. Moreover, no studies to date have included the role of both maternal and paternal sensitivity in child brain maturation. This study examined the prospective relation between mothers' and fathers' sensitive caregiving in early childhood and brain structure later in childhood.Method: Participants were enrolled in a population-based prenatal cohort. For 191 families, maternal and paternal sensitivity was repeatedly observed when the child was between 1 year and 4 years of age. Head circumference was assessed at 6 weeks, and brain structure was assessed using magnetic resonance imaging (MRI) measurements at 8 years of age.Results: Higher levels of parental sensitivity in early childhood were associated with larger total brain volume (adjusted beta = 0.15, p =.01) and gray matter volume (adjusted beta = 0.16, p =.01) at 8 years, controlling for infant head size. Higher levels of maternal sensitivity in early childhood were associated with a larger gray matter volume (adjusted beta = 0.13, p =.04) at 8 years, independent of infant head circumference. Associations with maternal versus paternal sensitivity were not significantly different.Conclusion: Normal variation in caregiving quality is related to markers of more optimal brain development in children. The results illustrate the important role of both mothers and fathers in child brain development.