Heritability of hunger relationships with food intake in free-living humans
Heritability of hunger relationships with food intake in free-living humans
复制标题
DOI：
10.1016/s0031-9384(99)00065-7
复制
发表时间：
1999-08-15
影响因子：
2.9
通讯作者：
De Castro, JM
中科院分区：
文献类型：
--
作者：
De Castro, JM
研究对象为 110 名同卵双胞胎、102 名异性异卵双胞胎和 53 名异性异卵双胞胎，他们有偿记录 7 天的食物摄入日记，研究了餐前和餐后饥饿和口渴的自我评价的遗传性及其与食物摄入的关系。根据日记报告，估算食物能量的总摄入量和膳食摄入量以及摄入的常量营养素的量。受试者在进食前和进食后按七分制对自己的主观饥饿程度进行评分。应用线性结构模型来研究遗传和环境影响的性质和程度，并揭示了遗传对餐前和餐后饥饿自评水平以及进餐期间饥饿变化的显着影响。此外，饥饿和摄入量之间的关系也受到基因的影响。研究发现，餐前饥饿感与膳食量以及餐后饥饿感与摄入量的变化之间的相关性和回归线的斜率具有显着的遗传性。这表明饥饿对摄入的影响以及摄入对饥饿的影响在某种程度上是可遗传的。这表明主观体验的水平和个体对它们的反应受到基因的影响，并成为基因决定的调节能量平衡的生理、社会/文化和心理过程的整体的一部分。 (C) 1999 爱思唯尔科学公司。
The heritability of the before and after meal self-ratings of hunger and thirst and their relationship to food intake was investigated with 110 identical and 102 fraternal same-sex and 53 fraternal mixed-gender adult twin pairs who were paid to maintain 7-day food intake diaries. From the diary reports, the total and meal intakes of food energy and the amounts of the macronutrients ingested were estimated. Subjects rated their subjective levels of hunger on a seven-point scale both before and after eating. Linear structural modeling was applied to investigate the nature and degree of genetic and environmental influences and revealed significant genetic influences on the self-rated levels of hunger both before and after the meals and the change in hunger over the meal. In addition, the relationship between hunger and intake was influenced by the genes. Significant heritabilities were found for the correlations, and the slopes of the regression lines relating before-meal hunger to meal size and also the change in hunger over the meal to intake. This indicates that hunger's effect on intake and, in turn, intake's effects on hunger are to some extent heritable. This suggests that the level of subjective experience and the individuals responses to them are influenced by the genes and become part of the total package of genetically determined physiological, socio/cultural, and psychological processes that regulate energy balance. (C) 1999 Elsevier Science Inc.