Cultured quail neural crest cells attain competence for terminal differentiation into melanocytes before competence to terminal differentiation into adrenergic neurons.
Cultured quail neural crest cells attain competence for terminal differentiation into melanocytes before competence to terminal differentiation into adrenergic neurons.
复制标题
培养的鹌鹑神经嵴细胞在具有终末分化为肾上腺素能神经元的能力之前获得终末分化为黑素细胞的能力。
DOI：
10.1016/0012-1606(83)90022-2
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发表时间：
1983
影响因子：
2.7
通讯作者：
Sieber-Blum,M
中科院分区：
文献类型：
--
作者：
Kahn,CR;Sieber-Blum,M
在迁移开始时，鹌鹑神经嵴包含多能祖细胞，其产生黑素细胞和肾上腺素能神经元以及已经致力于黑素生成或神经元通路的祖细胞。在本文中，我们表明，黑素祖细胞达到终端分化的能力之前，肾上腺素祖细胞。肾上腺素能表型仅在嵴细胞体外增殖至少3天后才表达。分化成黑素细胞，然而，发生即使增殖被阻断后立即阿糖胞苷的神经管。
At the onset of migration the quail neural crest contains pluripotent progenitor cells that give rise to both melanocytes and adrenergic neurons as well as progenitor cells that are already committed to the melanogenic or the neuronal pathway. In this paper we show that melanogenic progenitors attain the competence for terminal differentiation prior to adrenergic progenitors. The adrenergic phenotype was only expressed when the crest cells were allowed to proliferatein vitrofor at least 3 days. Differentiation into melanocytes, however, occurred even when proliferation was blocked with cytosine arabinoside immediately after explantation of the neural tube.