Radiation-induced carcinogenesis: Individual sensitivity and genomic instability
Radiation-induced carcinogenesis: Individual sensitivity and genomic instability
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辐射诱发的致癌作用：个体敏感性和基因组不稳定性
DOI：
10.1007/bf01209747
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发表时间：
1995
影响因子：
1.7
通讯作者：
B. Dutrillaux
中科院分区：
文献类型：
--
作者：
L. Sabatier;J. Lebeau;B. Dutrillaux
尽管辐射暴露与癌症风险增加之间存在众所周知的关系，但辐射诱发致癌的生物学机制仍鲜有文献记载。本文讨论了各种假设。辐射似乎不能直接导致癌细胞的大量基因改变。其中大多数发生在肿瘤进展过程中。其中只有一个或非常有限的数量是在肿瘤生长前多年由辐射诱导的。这种长时间的延迟是实验研究的一个主要困难，并提出了许多问题。最近，有研究表明，从受辐射的细胞传代下来的细胞在经过多次传代后会出现基因组不稳定性。这种不稳定性会导致多种基因改变，并优先影响某些染色体结构，特别是端粒。这种端粒不稳定性与端粒DNA序列缩短有关，在易患癌症的患者的衰老细胞和非衰老细胞中也观察到了这种端粒不稳定性，这一过程可能也发生在辐射细胞的后代中。
In spite of a well-known relationship between exposure to radiation and increased risk for cancer development, the biological mechanisms involved in radiation-induced carcinogenesis remain poorly documented. Various hypotheses are discussed in this paper. It appears that radiation cannot be directly responsible for the numerous genetic alterations of cancer cells. Most of them occur during tumor progression. Only one or a very limited number of them was induced by radiation many years before tumor growth. This long delay is a major difficulty for experimental research and raises many questions. Recently, it has been shown that a genomic instability occurs after many generations in cells descending from irradiated cells. This instability leads to multiple genetic alterations and, preferentially, affects some chromosome structures, particularly telomeres. This kind of telomeric instability - related to the shortening of telomeric DNA sequences - has also been observed in senescent cells as well as in non-senescent cells from patients predisposed to cancer, and this process may possibly also occur in the progeny of irradiated cells.
DOI：
10.1073/pnas.91.8.2900
发表时间：
1994-04-12
影响因子：
11.1
作者：
COUNTER, CM;HIRTE, HW;HARLEY, CB
通讯作者：
HARLEY, CB
影响因子：
56.9
作者：
AALTONEN, LA;PELTOMAKI, P;DELACHAPELLE, A
通讯作者：
DELACHAPELLE, A