Circadian rhythms. A circadian loop asSIRTs itself.
Circadian rhythms. A circadian loop asSIRTs itself.
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昼夜节律。
DOI：
10.1126/science.1174132
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wijnen,Herman
中科院分区：
文献类型：
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作者：
Wijnen,Herman
在许多生物体中，日常时间的保持依赖于内部生物钟，这些生物钟在时间上组织彼此之间以及与环境相关的生物功能。这些时钟通过使用在负反馈环路中组织的基因表达电路来产生生理和行为的节奏。这一问题中的两项研究，由Nakahataet等人在第654页上和Ramseyer等人在第651页上提出，建议在这个电路中增加一个新的负反馈回路，涉及代谢物烟酰胺腺嘌呤二核苷酸(NAD+)和蛋白质SIRTUIN1(SIRT1)。新的环路表明生物钟和SIRT1依赖的功能之间存在联系，这些功能与细胞的生存、发育、炎症和新陈代谢有关。
Daily time keeping in many organisms depends on internal circadian clocks that temporally organize biological functions relative to each other as well as the environment. These clocks generate rhythms in physiology and behavior by using circuits of gene expression that are organized in negative-feedback loops . Two studies in this issue, by Nakahataet al.on page 654 and Ramseyet al.on page 651, propose the addition of a new negative-feedback loop to this circuitry that involves the metabolite nicotinamide adenine dinucleotide (NAD+) and the protein SIRTUIN1 (SIRT1). The new loop suggests connections between the circadian clock and SIRT1-dependent functions associated with cell survival, development, inflammation, and metabolism.