The molecular and cellular basis of thermosensation in mammals.
The molecular and cellular basis of thermosensation in mammals.
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DOI：
10.1016/j.conb.2015.01.010
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发表时间：
2015-10
影响因子：
5.7
通讯作者：
McKemy DD
中科院分区：
文献类型：
--
作者：
Palkar R;Lippoldt EK;McKemy DD
超过十五年的深入研究表明，瞬时受体电位家族离子通道TRPV1和TRPM8是外周神经系统中热和冷温度的主要传感器。TRPV同源物和TRPA1也有牵连，但最近的遗传证据已经减少了它们在热敏中的意义，并表明一些新发现的热敏通道，包括TRPM3，双孔钾通道和氯离子通道Ano1，需要进一步考虑。除了新型热传导器之外，最近的遗传和药理学方法也开始阐明温度感觉背后的传入神经回路，继续快速扩展我们对温度感觉的细胞和分子基础的理解，这始于TRPV 1和TRPM 8的发现。
Over a decade and a half of intensive study has shown that the Transient Receptor Potential family ion channels TRPV1 and TRPM8 are the primary sensors of heat and cold temperatures in the peripheral nervous system. TRPV homologues and TRPA1 are also implicated, but recent genetic evidence has diminished their significance in thermosensation and suggests that a number of newly identified thermosensitive channels, including TRPM3, two-pore potassium channels, and the chloride channel Ano1, require further consideration. In addition to novel thermostransducers, recent genetic and pharmacological approaches have begun to elucidate the afferent neurocircuits underlying temperature sensation, continuing the rapid expansion in our understanding of the cellular and molecular basis of thermosensation that began with the discovery of TRPV1 and TRPM8.