Estrogen inhibits colon polyp formation by reducing angiogenesis in a carcinogen-induced rat model.
Estrogen inhibits colon polyp formation by reducing angiogenesis in a carcinogen-induced rat model.
复制标题
雌激素通过减少致癌物诱导的大鼠模型中的血管生成来抑制结肠息肉形成
DOI：
10.1155/2013/453898
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发表时间：
2013
影响因子：
2.8
通讯作者：
Wang GB
中科院分区：
文献类型：
--
作者：
Yang J;Xiong LJ;Xu F;Zhao X;Liu B;Cai KL;Wang GB
Objective.研究雌激素对二甲基肼（DMH）诱导的大鼠结肠癌模型结肠息肉形成、增殖及血管生成的影响。方法.将36只去卵巢雌性大鼠随机分为3组：（I）对照组（每周给予溶媒）、（II）DMH组（每周给予DMH）和（III）DMH + E2组（每周给予DMH和17β-雌二醇）。评价各组结肠息肉的发生率、体积和多样性。检测各组息肉中微血管密度（MVD）、增殖细胞核抗原（PCNA）表达、HIF-1α和VEGF表达。结果雌激素降低DMH诱导的结肠息肉的多样性、体积和PCNA表达。DMH + E2组MVD明显低于DMH组。雌激素处理可降低HIF-1α和VEGF在mRNA和蛋白水平的表达。结论雌激素替代治疗对DMH诱发的卵巢癌具有保护作用，其机制之一是通过下调VEGF和HIF-1α表达抑制血管形成。
Objective. To study the effects of estrogen on colon polyp formation, proliferation, and angiogenesis on a rat model of colon cancer induced by dimethylhydrazine (DMH). Methods. Thirty-six female ovariectomized (OVX) rats were randomly divided into 3 groups: (I) control group (administrated with vehicles weekly), (II) DMH group (administrated with DMH weekly), and (III) DMH + E2 group (administrated with DMH and 17β-estradiol weekly). The incidence, volumes, and multiplicity of colon polyps in each group were evaluated. The microvessel density (MVD), the expressions of Proliferating Cell Nuclear Antigen (PCNA), and the expressions of HIF-1α and VEGF in polyps were detected in each group. Results. Estrogen reduced the multiplicity, volumes, and the PCNA expressions of DMH-induced colon polyps. The MVD in DMH + E2 group was significantly lower than that in DMH group. Estrogen treatment decreased the HIF-1α and VEGF expressions at both mRNA and protein level. Conclusion. Estrogen replacement was protective for ovariectomized rats from DMH-induced carcinogenesis, and one of the mechanisms for this was due to estrogen's inhibitive effects on blood vessel formation by downregulating VEGF and HIF-1α expressions.
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影响因子：
158.5
作者：
Chlebowski, RT;Wactawski-Wende, J;Carleton, R
通讯作者：
Carleton, R
影响因子：
4.3
作者：
Naumov, George N.;Akslen, Lars A.;Folkman, Judah
通讯作者：
Folkman, Judah
影响因子：
4.8
作者：
Nakamura, J;Savinov, A;Brodie, A
通讯作者：
Brodie, A
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J
影响因子：
2.8
作者：
Xu, Fei;Wang, Guobin;Tang, Shouyuan
通讯作者：
Tang, Shouyuan