DEFENSE SYSTEM PSYCHOPHARMACOLOGY - AN ETHOLOGICAL APPROACH TO THE PHARMACOLOGY OF FEAR AND ANXIETY
DEFENSE SYSTEM PSYCHOPHARMACOLOGY - AN ETHOLOGICAL APPROACH TO THE PHARMACOLOGY OF FEAR AND ANXIETY
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DOI：
10.1016/0166-4328(93)90100-5
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发表时间：
1993-12-20
影响因子：
2.7
通讯作者：
BLANCHARD, DC
中科院分区：
文献类型：
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作者：
BLANCHARD, RJ;YUDKO, EB;BLANCHARD, DC
防御行为包括对威胁情况和刺激的一系列灵活和适应性反应。在提供各种各样反应的半自然情况下，防御行为随着时间的推移而改变，以响应通过风险评估活动获得的关于危险存在的信息。两个测试组，一个是恐惧/防御测试组（F/DTB），测量对出现的防御行为，接近捕食者，另一个是焦虑/防御测试组（a /DTB），测量对潜在威胁的反应，与潜在抗焦虑药物的管理一起使用。结果表明，F/DTB行为对抗焦虑药没有系统反应。然而，在A/DTB上，抗焦虑苯二氮卓类药物产生的影响主要涉及风险评估活动。在一些5-HT1A化合物、酒精、丙咪嗪和MK-801中也可以看到非常相似的效果，但对各种其他化合物则没有效果。在A/DTB中获得了一致的性别差异模式，女性比男性更具防御性。这些结果表明，特定的防御行为模式可以为分析焦虑的药理作用提供一个非常合适的动物模型。
Defensive behaviors comprise a set of flexible and adaptive responses to threatening situations and stimuli. In semi-natural situations affording a wide variety of responses, defensive behaviors change over time in response to information about the presence of danger, acquired through risk assessment activities. Two test batteries, a Fear/Defense Test Battery (F/DTB) measuring defensive behaviors to present, approaching predators, and an Anxiety/Defense Test Battery (A/DTB) measuring reactions to potential threat, have been used in conjunction with administration of potentially anxiolytic drugs. Results suggest that the F/DTB behaviors are not systematically responsive to anxiolytics. However, on the A/DTB, anxiolytic benzodiazepines produce a profile of effects primarily involving risk assessment activities. Very similar profiles of effect are seen also with some 5-HT1A compounds, alcohol, imipramine and MK-801, but not for a variety of additional compounds. A consistent pattern of gender differences are obtained with the A/DTB, with females more defensive than males. These results indicate that particular patterns of defensive behaviors may provide a very appropriate animal model for the analysis of pharmacological effects on anxiety.